A key and highly regulated enzyme that is required for the biosynthesis of monounsaturated
fatty acids is stearoyl-CoA desaturase (SCD), which catalyzes the D9-cis desaturation of a …

Stearoyl‐CoA desaturase 1 (SCD1) is an essential lipogenic enzyme that has been shown
to play an intrinsic role in the development of obesity and related conditions, such as insulin …

Comparison between groups of monozygotic (MZ) and dizygotic (DZ) twins enables an
estimation of the relative contribution of genetic and shared and nonshared environmental …

In various embodiments, the present invention provides methods of reducing the risk of a
cardiovascular event in a subject on statin therapy and, in particular, a method of reducing …

The molecular bases of Alzheimer's disease (AD) remain unclear. We used a lipidomic
approach to identify lipid abnormalities in the brains of subjects with AD (N= 37) compared …

Obesity is currently a worldwide epidemic and public health burden that increases the risk
for developing insulin resistance and several chronic diseases such as diabetes …

US9814733B2 - Compositions comprising EPA and obeticholic acid and methods of use
thereof - Google Patents US9814733B2 - Compositions comprising EPA and obeticholic …

The present invention relates to, inter alia, pharmaceutical compositions comprising EPA
and one or more cardiovascular agents, and to therapeutic methods for treating various …

Although omega-3 (n− 3) fatty acids negatively regulate triglyceride biosynthesis, the
mechanisms mediating this effect are poorly understood, and emerging evidence suggests …

Aims Maternal obesity and gestational diabetes mellitus (GDM) were frequently reported to
be risk factors for obesity and diabetes in offspring. Our goal was to study the impact of …