Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Molecular dynamics (MD) simulations have become increasingly useful in the modern drug
development process. In this review, we give a broad overview of the current application …

Lysine L-lactylation [K (L-la)] is a newly discovered histone mark stimulated under conditions
of high glycolysis, such as the Warburg effect. K (L-la) is associated with functions that are …

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein
deacylation is a unique feature of the family of proteins called 'sirtuins.'This intimate …

In diabetes mellitus, the polyol pathway is highly active and consumes approximately 30%
glucose in the body. This pathway contains 2 reactions catalyzed by aldose reductase (AR) …

Sirtuins are NAD+-dependent protein deacylases that regulate several aspects of
metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic …

The mechanisms underlying the formation of acyl protein modifications remain poorly
understood. By investigating the reactivity of endogenous acyl-CoA metabolites, we found a …