Abstract Calcium dysregulation (“Calcium Hypothesis”) is an early and critical event in
Alzheimer's and other neurodegenerative diseases. Calcium binds to and regulates the …

The nucleus is ultimately the final target for many therapeutics treating various disorders
including cancers, heart dysfunction and brain disorders. Owing to their specialized cell …

Small-conductance Ca2+-activated K+ (SK) channels mediate neuron excitability and are
associated with synaptic transmission and plasticity. They also regulate immune responses …

Calmodulin (CaM) is a Ca2+-sensing protein that is highly conserved and ubiquitous in
eukaryotes. In humans it is a locus of life-threatening cardiomyopathies. The primary …

Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a
critical second messenger involved in numerous biological activities through extensive …

Tight regulation of neuronal transport allows for cargo binding and release at specific
cellular locations. The mechanisms by which motor proteins are loaded on vesicles and how …

SynGAP is a Ras/Rap GTPase-activating protein (GAP) that is a major constituent of
postsynaptic densities (PSDs) from mammalian forebrain. Its α1 isoform binds to all three …

Neurodegeneration leads to multiple early changes in cognitive, emotional, and social
behaviours and ultimately progresses to dementia. The dysregulation of calcium is one of …

Plant viruses are the most abundant destructive agents that exist in every ecosystem,
causing severe diseases in multiple crops worldwide. Currently, a major gap is present in …

The physical interactome of a protein can be altered upon perturbation, modulating cell
physiology and contributing to disease. Identifying interactome differences of normal and …