Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

Background The literature on the epidemiology, mortality and treatment of pandrug-resistant
(PDR) Gram-negative bacteria (GNB) is scarce, scattered and controversial. Objectives To …

The management of carbapenem-resistant infections is often based on polymyxins,
tigecycline, aminoglycosides and their combinations. However, in a recent systematic …

Background: The superiority of combination therapy for carbapenem-resistant Gram-
negative bacilli (CR-GNB) remains controversial. In vitro models may predict the efficacy of …

In this review, we provide an updated summary on colistin pharmacokinetics and
pharmacodynamics. Colistin is an old molecule that is frequently used as last-line treatment …

Introduction Acinetobacter baumannii antimicrobial resistance is a public health concern in
developing and developed countries, especially in the hospital setting. Understanding the …

Antimicrobial combinations are at the moment the only potential treatment option for
pandrug-resistant A. baumannii. A systematic review was conducted in PubMed and Scopus …

Horizontal gene transfer (HGT) is a driving force to the evolution of bacteria. The fast
emergence of antimicrobial resistance reflects the ability of genetic adaptation of pathogens …

Fosfomycin is being increasingly prescribed for multidrug-resistant bacterial infections. In
patients with systemic involvement, intravenous fosfomycin is usually administered as a …

This study aimed to investigate the biofilm-production ability of carbapenem-resistant
Acinetobacter baumannii (CRAB), the biofilm-eradication potential of 70% ethanol and 0.5 …