[HTML][HTML] Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms, and therapeutic targets in atopic diseases
Type 2 inflammation is characterized by overexpression and heightened activity of type 2
cytokines, mediators and cells that drive neuroimmune activation and sensitization to …
cytokines, mediators and cells that drive neuroimmune activation and sensitization to …
Neuroimmune recognition and regulation in the respiratory system
J Chen, X Lai, Y Song, X Su - European Respiratory Review, 2024 - publications.ersnet.org
Neuroimmune recognition and regulation in the respiratory system is a complex and highly
coordinated process involving interactions between the nervous and immune systems to …
coordinated process involving interactions between the nervous and immune systems to …
A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice
Coughing is a respiratory behavior that plays a crucial role in protecting the respiratory
system. Here we show that the nucleus of the solitary tract (NTS) in mice contains …
system. Here we show that the nucleus of the solitary tract (NTS) in mice contains …
Brainstem Dbh+ neurons control allergen-induced airway hyperreactivity
Exaggerated airway constriction triggered by repeated exposure to allergen, also called
hyperreactivity, is a hallmark of asthma. Whereas vagal sensory neurons are known to …
hyperreactivity, is a hallmark of asthma. Whereas vagal sensory neurons are known to …
Lung-innervating nociceptor sensory neurons promote pneumonic sepsis during carbapenem-resistant Klebsiella pneumoniae lung infection
Carbapenem-resistant Klebsiella pneumoniae (CRKP) causes Gram-negative lung
infections and fatal pneumonic sepsis for which limited therapeutic options are available …
infections and fatal pneumonic sepsis for which limited therapeutic options are available …
Neuroimmune interactions in the lung
Barrier tissues are highly innervated by sensory and autonomic nerves that are positioned in
close proximity to both stromal and immune cell populations. Together with a growing …
close proximity to both stromal and immune cell populations. Together with a growing …
Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction
W Yu, TO Moninger, MV Rector, DA Stoltz, MJ Welsh - Developmental cell, 2022 - cell.com
Pulmonary neuroendocrine cells (PNECs) are rare airway cells with potential sensory
capacity linked to vagal neurons and immune cells. How PNECs sense and respond to …
capacity linked to vagal neurons and immune cells. How PNECs sense and respond to …
[HTML][HTML] Sensory neurons promote immune homeostasis in the lung
M Tamari, KL Del Bel, AM Ver Heul, L Zamidar… - Cell, 2024 - cell.com
Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory
diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with …
diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with …
A novel Flp reporter mouse shows that TRPA1 expression is largely limited to sensory neuron subsets
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal cation channel that is
activated by electrophilic irritants, oxidative stress, cold temperature, and GPCR signaling …
activated by electrophilic irritants, oxidative stress, cold temperature, and GPCR signaling …
[HTML][HTML] Neuro-immune crosstalk in hematopoiesis, inflammation, and repair
DE Akinyemi, R Chevre, O Soehnlein - Trends in Immunology, 2024 - cell.com
Innate immune cells are primary effectors during host defense and in sterile inflammation.
Their production in the bone marrow is tightly regulated by growth and niche factors, and …
Their production in the bone marrow is tightly regulated by growth and niche factors, and …