Role of O-linked N-acetylglucosamine protein modification in cellular (patho)physiology
In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …
Analytical and biochemical perspectives of protein O-GlcNAcylation
Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …
unique monosaccharide modification discovered in the early 1980s. With the technological …
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1
Q Zhu, H Zhou, L Wu, Z Lai, D Geng, W Yang… - Nature Chemical …, 2022 - nature.com
Oncogenic Kras-activated pancreatic ductal adenocarcinoma (PDAC) cells highly rely on an
unconventional glutamine catabolic pathway to sustain cell growth. However, little is known …
unconventional glutamine catabolic pathway to sustain cell growth. However, little is known …
Advances in chemical probing of protein O-GlcNAc glycosylation: structural role and molecular mechanisms
A Saha, D Bello, A Fernández-Tejada - Chemical Society Reviews, 2021 - pubs.rsc.org
The addition of O-linked-β-DN-acetylglucosamine (O-GlcNAc) onto serine and threonine
residues of nuclear and cytoplasmic proteins is an abundant, unique post-translational …
residues of nuclear and cytoplasmic proteins is an abundant, unique post-translational …
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase
Abstract O-linked N-acetylglucosamine (O-GlcNAc) is an essential and dynamic post-
translational modification that is presented on thousands of nucleocytoplasmic proteins …
translational modification that is presented on thousands of nucleocytoplasmic proteins …
Release of O-GlcNAc transferase inhibitor promotes neuronal differentiation of neural stem cells in 3D bioprinted supramolecular hydrogel scaffold for spinal cord …
X Liu, S Song, Z Chen, C Gao, Y Li, Y Luo, J Huang… - Acta biomaterialia, 2022 - Elsevier
Precise fabrication of biomimetic three-dimensional (3D) structure and effective neuronal
differentiation under the pathological environment are the key to neural stem cell (NSC) …
differentiation under the pathological environment are the key to neural stem cell (NSC) …
Engineering a proximity-directed O-GlcNAc transferase for selective protein O-GlcNAcylation in cells
DH Ramirez, C Aonbangkhen, HY Wu… - ACS chemical …, 2020 - ACS Publications
O-Linked β-N-acetylglucosamine (O-GlcNAc) is a monosaccharide that plays an essential
role in cellular signaling throughout the nucleocytoplasmic proteome of eukaryotic cells …
role in cellular signaling throughout the nucleocytoplasmic proteome of eukaryotic cells …
Tools, tactics and objectives to interrogate cellular roles of O-GlcNAc in disease
C Fehl, JA Hanover - Nature chemical biology, 2022 - nature.com
The vast array of cell types of multicellular organisms must individually fine-tune their
internal metabolism. One important metabolic and stress regulatory mechanism is the …
internal metabolism. One important metabolic and stress regulatory mechanism is the …
[HTML][HTML] Systematic analysis of the impact of phosphorylation and O-GlcNAcylation on protein subcellular localization
The subcellular localization of proteins is critical for their functions in eukaryotic cells and is
tightly correlated with protein modifications. Here, we comprehensively investigate the …
tightly correlated with protein modifications. Here, we comprehensively investigate the …
Mammalian cell proliferation requires noncatalytic functions of O-GlcNAc transferase
O-GlcNAc transferase (OGT), found in the nucleus and cytoplasm of all mammalian cell
types, is essential for cell proliferation. Why OGT is required for cell growth is not known …
types, is essential for cell proliferation. Why OGT is required for cell growth is not known …