The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus attacks multiple
organs of coronavirus disease 2019 (COVID-19) patients, including the brain. There are …

Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding
cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator …

Cerebral edema and contusion expansion are major determinants of morbidity and mortality
after TBI. Current treatment options are reactive, suboptimal and associated with significant …

Introduction Cerebral edema is a key contributor to death and disability in several forms of
brain injury. Current treatment options are limited, reactive, and associated with significant …

Glibenclamide (GLY) is the sixth drug tested by the Operation Brain Trauma Therapy (OBTT)
consortium based on substantial pre-clinical evidence of benefit in traumatic brain injury …

Purpose of review The purposes of this narrative review are to (1) summarize a
contemporary view of cerebral edema pathophysiology,(2) present a synopsis of current …

ABSTRACT BACKGROUND AND PURPOSE Brain edema after acute cerebral lesions may
lead to raised intracranial pressure (ICP) and worsen outcome. Notwithstanding, no CT …

The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is
significant, and the heterogeneity of TBI patients and the relatively small sample sizes of …

Importance Intracerebral hemorrhage progression is associated with unfavorable outcome
after traumatic brain injury (TBI). No effective treatments are currently available. This …

OBJECTIVES: Addressing traumatic brain injury (TBI) heterogeneity is increasingly
recognized as essential for therapy translation given the long history of failed clinical trials …