Most cancer-related deaths are caused by the metastases, which commonly develop at
multiple organ sites including the brain, bone, and lungs. Despite longstanding observations …

Elucidating the chemical structure and intracellular action mechanisms is still the critical limit
for the clinical translation of nanomedicines. Intracellular redox environments originating …

Metabolic rewiring is essential for tumor growth and progression to metastatic disease, yet
little is known regarding how cancer cells modify their acquired metabolic programs in …

Aims Oxidative stress reflected by elevated reactive oxygen species (ROS) in the tumor
ecosystem, is a hallmark of human cancers. The mechanisms by which oxidative stress …

Background Studies have shown that oxidative stress and its resistance plays important
roles in the process of tumor metastasis, and mitochondrial dysfunction caused by …

As one of the most prevalent digestive system tumours, colorectal cancer (CRC) poses a
significant threat to global human health. With the emergence of immunotherapy and target …

Significant efforts have focused on identifying targetable genetic drivers that support the
growth of solid tumors and/or increase metastatic ability. During tumor development and …

Eukaryotic initiation translation factor 3 subunit h (EIF3H) plays critical roles in regulating
translational initiation and predicts poor cancer prognosis, but the mechanism underlying …

In colorectal cancer (CRC), increased numbers of tumor-infiltrating CD4+ regulatory T (Treg)
cells correlate with tumor development and immunotherapy failure, leading to poor …

Introduction: Anticancer drugs with reactive oxygen species-inducing mechanisms, such as
vemurafenib, have been shown to be effective against various types of cancer. However, the …