The multifaceted roles of copper in cancer: A trace metal element with dysregulated metabolism, but also a target or a bullet for therapy
Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …
can be detrimental for the cell that developed highly coordinated pathways to chelate and …
Tumour targeting with radiometals for diagnosis and therapy
CF Ramogida, C Orvig - Chemical Communications, 2013 - pubs.rsc.org
Use of radiometals in nuclear oncology is a rapidly growing field and encompasses a broad
spectrum of radiotracers for imaging via PET (positron emission tomography) or SPECT …
spectrum of radiotracers for imaging via PET (positron emission tomography) or SPECT …
Recent advances in radiometals for combined imaging and therapy in cancer
N Herrero Álvarez, D Bauer, J Hernández‐Gil… - …, 2021 - Wiley Online Library
Nuclear medicine is defined as the use of radionuclides for diagnostic and therapeutic
applications. The imaging modalities positron emission tomography (PET) and single …
applications. The imaging modalities positron emission tomography (PET) and single …
The chemical scaffold of theranostic radiopharmaceuticals: radionuclide, bifunctional chelator, and pharmacokinetics modifying linker
Therapeutic radiopharmaceuticals have been researched extensively in the last decade as
a result of the growing research interest in personalized medicine to improve diagnostic …
a result of the growing research interest in personalized medicine to improve diagnostic …
The emerging role of copper-64 radiopharmaceuticals as cancer theranostics
A Boschi, P Martini, E Janevik-Ivanovska, A Duatti - Drug Discovery Today, 2018 - Elsevier
Highlights•Copper radionuclides for in vivo imaging of biological functions of copper
ions.•Copper-64 has suitable nuclear properties for cancer theranostics.•Radioactive copper …
ions.•Copper-64 has suitable nuclear properties for cancer theranostics.•Radioactive copper …
Customizable Porphyrin Platform Enables Folate Receptor PET Imaging Using Copper-64
Folate receptors including folate receptor α (FRα) are overexpressed in up to 90% of ovarian
cancers. Ovarian cancers overexpressing FRα often exhibit high degrees of drug resistance …
cancers. Ovarian cancers overexpressing FRα often exhibit high degrees of drug resistance …
Copper radiopharmaceuticals for theranostic applications
A Ahmedova, B Todorov, N Burdzhiev… - European Journal of …, 2018 - Elsevier
The growing advancement in nuclear medicine challenges researchers from several
different fields to integrate imaging and therapeutic modalities in a theranostic …
different fields to integrate imaging and therapeutic modalities in a theranostic …
64Cu2+ Ions as PET Probe: An Emerging Paradigm in Molecular Imaging of Cancer
Positron emission tomography (PET) imaging has transformed diagnostic nuclear medicine
and become an essential strategy in cancer management. With the expected growth of this …
and become an essential strategy in cancer management. With the expected growth of this …
H2CHXdedpa and H4CHXoctapaChiral Acyclic Chelating Ligands for 67/68Ga and 111In Radiopharmaceuticals
CF Ramogida, JF Cawthray, E Boros… - Inorganic …, 2015 - ACS Publications
The chiral acyclic ligands H2 CHX dedpa (N4O2), H2 CHX dedpa-bb (N4O2), and H4 CHX
octapa (N4O4)(CHX= cyclohexyl/cyclohexane, H2dedpa= 1, 2-[[6-carboxy-pyridin-2-yl] …
octapa (N4O4)(CHX= cyclohexyl/cyclohexane, H2dedpa= 1, 2-[[6-carboxy-pyridin-2-yl] …
RGD‐based PET tracers for imaging receptor integrin αvβ3 expression
Positron emission tomography (PET) imaging of receptor integrin αvβ3 expression may play
a key role in the early detection of cancer and cardiovascular diseases, monitoring disease …
a key role in the early detection of cancer and cardiovascular diseases, monitoring disease …