The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action

SE Murphy, LP Capitão, SLC Giles, PJ Cowen… - The Lancet …, 2021 - thelancet.com
The use of SSRIs for the treatment of depression and anxiety in young people is increasing.
However, the effects of SSRIs in adolescence, a time when there are substantial changes in …

Cognitive Behavioral therapy for anxiety disorders in youth: efficacy, moderators, and new advances in predicting outcomes

S Pegg, K Hill, A Argiros, BO Olatunji… - Current psychiatry reports, 2022 - Springer
Abstract Purpose of Review This review integrates recent systematic reviews and meta-
analyses on the efficacy of cognitive behavioral therapy (CBT) for the treatment of anxiety …

[HTML][HTML] Structural and functional neuroimaging studies in generalized anxiety disorder: a systematic review

D Madonna, G Delvecchio, JC Soares… - Brazilian Journal of …, 2019 - SciELO Brasil
Objectives: Brain imaging studies carried out in patients suffering from generalized anxiety
disorder (GAD) have contributed to better characterize the pathophysiological mechanisms …

Cognitive control in pediatric obsessive-compulsive and anxiety disorders: brain-behavioral targets for early intervention

KD Fitzgerald, HS Schroder, R Marsh - Biological Psychiatry, 2021 - Elsevier
The DSM provides distinct criteria for obsessive-compulsive disorder (OCD) and various
types of anxiety disorders, but phenomenological overlap, high rates of comorbidity, and …

Moderators of outcome for youth anxiety treatments: Current findings and future directions

LA Norris, PC Kendall - Journal of Clinical Child & Adolescent …, 2021 - Taylor & Francis
Objective: To improve outcomes and create more personalized interventions, the field has
sought to identify moderators of treatment response (variables that specify which treatments …

[HTML][HTML] Neurocircuitry of treatment in anxiety disorders

WT Baumel, L Lu, X Huang, AT Drysdale… - Biomarkers in …, 2022 - Elsevier
Background Understanding how treatments change neurobiology is critical to developing
predictors of treatment response. This is especially true for anxiety disorders—the most …

Neural activation changes following attention bias modification treatment or a selective serotonin reuptake inhibitor for social anxiety disorder

O Azriel, G Arad, N Tik, M Weiser, M Bloch… - Psychological …, 2024 - cambridge.org
BackgroundDelineation of changes in neural function associated with novel and established
treatments for social anxiety disorder (SAD) can advance treatment development. We …

Reduced reward responsiveness predicts change in depressive symptoms in anxious children and adolescents following treatment

A Kujawa, KL Burkhouse, SR Karich… - Journal of Child and …, 2019 - liebertpub.com
Objectives: Reduced reward responsiveness, as measured by the event-related potential
(ERP) component, the reward positivity (RewP), has been shown to play a role in the …

Acute neurofunctional effects of escitalopram in pediatric anxiety: a double-blind, placebo-controlled trial

L Lu, JA Mills, H Li, HK Schroeder, SA Mossman… - Journal of the American …, 2021 - Elsevier
Objective Amygdala− ventrolateral prefrontal cortex (VLPFC) circuitry is disrupted in
pediatric anxiety disorders, yet how selective serotonin reuptake inhibitors (SSRIs) affect this …

Neural correlates of cognitive behavioral therapy response in youth with negative valence disorders: A systematic review of the literature

V La Buissonniere-Ariza, K Fitzgerald… - Journal of Affective …, 2021 - Elsevier
Background Cognitive-behavioral therapy (CBT) is the gold-standard psychotherapeutic
treatment for pediatric negative valence disorders. However, some youths do not respond …