Precise regulation of the amplitude and duration of receptor tyrosine kinase (RTK) signaling
is critical for the execution of cellular programs and behaviors. Understanding these control …

Physiological equilibrium in the retina depends on coordinated work between rod and cone
photoreceptors and can be compromised by the expression of mutant proteins leading to …

Mutations in the cilia-centrosomal protein CEP290 are frequently observed in autosomal
recessive childhood blindness disorder Leber congenital amaurosis (LCA). No treatment or …

Mutations in CEP290 cause ciliogenesis defects, leading to diverse clinical phenotypes,
including Leber congenital amaurosis (LCA). Gene therapy for CEP290-associated …

Opioids remain the standard for analgesic care; however, adverse effects of systemic
treatments contraindicate long-term administration. While most clinical opioids target mu …

Cilia regulate several developmental and homeostatic pathways that are critical to survival.
Sensory cilia of photoreceptors regulate phototransduction cascade for visual processing …

An integrated stress response (ISR), identified in several different animal models of inherited
retinal degeneration (IRD), is activated following various cellular stresses. The ISR results in …

It is unclear how genes, such as RPGR (retinitis pigmentosa guanine triphosphatase
regulator) that are expressed in both rods and cones, cause variable disease pathogenesis …

Activation of the unfolded protein response has been detected in various animal models of
retinal degeneration. The PERK branch converges on eIF2α to regulate protein synthesis …

Purpose: We reported previously that retinas of mice with inherited retinal degeneration
make less protein than retinas of normal mice. Despite recent studies suggesting that …