Long noncoding RNAs in cancer metastasis

SJ Liu, HX Dang, DA Lim, FY Feng… - Nature Reviews Cancer, 2021 - nature.com
Metastasis is a major contributor to cancer-associated deaths. It is characterized by a
multistep process that occurs through the acquisition of molecular and phenotypic changes …

EZH2: a novel target for cancer treatment

R Duan, W Du, W Guo - Journal of hematology & oncology, 2020 - Springer
Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive
complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of …

The long and short non-coding RNAs modulating EZH2 signaling in cancer

S Mirzaei, MH Gholami, K Hushmandi… - Journal of hematology & …, 2022 - Springer
Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …

New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

ZT Yao, YM Yang, MM Sun, Y He, L Liao… - Cancer …, 2022 - Wiley Online Library
With the development of proteomics and epigenetics, a large number of RNA‐binding
proteins (RBPs) have been discovered in recent years, and the interaction between long …

LncRNA-mediated regulation of cell signaling in cancer

WX Peng, P Koirala, YY Mo - Oncogene, 2017 - nature.com
To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered
through functional genomics studies. Importantly, lncRNAs have been shown, in many …

Therapeutic targeting of long non-coding RNAs in cancer

G Arun, SD Diermeier, DL Spector - Trends in molecular medicine, 2018 - cell.com
Long non-coding RNAs (lncRNAs) represent a significant population of the human
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …

Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury

K Xiao, W He, W Guan, F Hou, P Yan, J Xu… - Cell death & …, 2020 - nature.com
Acute lung injury (ALI) is a pulmonary disorder, which can result in fibrosis of the lung
tissues. Recently, mesenchymal stem cell (MSC) has become a novel therapeutic method …

Non-coding RNAs regulation of macrophage polarization in cancer

S Mohapatra, C Pioppini, B Ozpolat, GA Calin - Molecular cancer, 2021 - Springer
Noncoding RNA (ncRNA) transcripts that did not code proteins but regulate their functions
were extensively studied for the last two decades and the plethora of discoveries have …

[HTML][HTML] Long non-coding RNA and RNA-binding protein interactions in cancer: experimental and machine learning approaches

H Shaath, R Vishnubalaji, R Elango… - Seminars in cancer …, 2022 - Elsevier
Understanding the complex and specific roles played by non-coding RNAs (ncRNAs), which
comprise the bulk of the genome, is important for understanding virtually every hallmark of …

Long noncoding RNAs and exosomal lncRNAs: classification, and mechanisms in breast cancer metastasis and drug resistance

H Yousefi, M Maheronnaghsh, F Molaei, L Mashouri… - Oncogene, 2020 - nature.com
Breast cancer is the most common cancer, and the second cause of cancer-related deaths
(after lung cancer) among women. Developing tumor metastasis and invasion is the most …