The immune and regenerative response to burn injury

M Burgess, F Valdera, D Varon, E Kankuri, K Nuutila - Cells, 2022 - mdpi.com
Burn are diverse and complex injuries that not only have local effects but also serious
systemic consequences through severe and prolonged inflammatory response. They are …

A linkage between angiogenesis and inflammation in neovascular age-related macular degeneration

H Heloterä, K Kaarniranta - Cells, 2022 - mdpi.com
Age-related macular degeneration (AMD) is the leading cause of visual impairment in the
aging population with a limited understanding of its pathogenesis and the number of …

A cell atlas foundation model for scalable search of similar human cells

G Heimberg, T Kuo, DJ DePianto, O Salem, T Heigl… - Nature, 2024 - nature.com
Single-cell RNA-seq (scRNA-seq) has profiled hundreds of millions of human cells across
organs, diseases, development, and perturbations to date. Mining these growing atlases …

Pathophysiology of inflammatory bowel disease: innate immune system

A Saez, B Herrero-Fernandez, R Gomez-Bris… - International journal of …, 2023 - mdpi.com
Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis
(UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause …

Scalable querying of human cell atlases via a foundational model reveals commonalities across fibrosis-associated macrophages

G Heimberg, T Kuo, D DePianto, T Heigl, N Diamant… - BioRxiv, 2023 - biorxiv.org
Single-cell RNA-seq (scRNA-seq) studies have profiled over 100 million human cells across
diseases, developmental stages, and perturbations to date. A singular view of this vast and …

IFN-γ: An overlooked cytokine in dermatomyositis with anti-MDA5 antibodies

J Thuner, F Coutant - Autoimmunity Reviews, 2023 - Elsevier
Dermatomyositis with anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5
DM) is a rare autoimmune disease, often complicated by life-threatening, rapidly progressive …

[HTML][HTML] Targeting macrophage polarization for reinstating homeostasis following tissue damage

Q Du, A Dickinson, P Nakuleswaran… - International Journal of …, 2024 - mdpi.com
Tissue regeneration and remodeling involve many complex stages. Macrophages are
critical in maintaining micro-environmental homeostasis by regulating inflammation and …

Targeting pathogenic macrophages by the application of SHP-1 agonists reduces inflammation and alleviates pulmonary fibrosis

SY Hong, YT Lu, SY Chen, CF Hsu, YC Lu… - Cell Death & …, 2023 - nature.com
Idiopathic pulmonary fibrosis is a progressive fibrotic disorder with no cure that is
characterized by deterioration of lung function. Current FDA-approved drugs for IPF delay …

Osteointegration of Ti bone implants: A study on how surface parameters control the foreign body response

A Mesa-Restrepo, E Byers, JL Brown… - ACS Biomaterials …, 2024 - ACS Publications
The integration of titanium (Ti)-based implants with bone is limited, resulting in implant
failure. This lack of osteointegration is due to the foreign body response (FBR) that occurs …

Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis

Y Wang, S Chen, S Bao, L Yao, Z Wen, L Xu… - Frontiers in …, 2024 - frontiersin.org
This review explores the mechanisms of chronic radiation-induced skin injury fibrosis,
focusing on the transition from acute radiation damage to a chronic fibrotic state. It reviewed …