[HTML][HTML] Role of IL-6 in the regulation of neuronal development, survival and function
The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …
and destructive potentials. It can exert opposing actions triggering either neuron survival …
Interleukin-6: an emerging regulator of pathological pain
YQ Zhou, Z Liu, ZH Liu, SP Chen, M Li… - Journal of …, 2016 - Springer
Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been
widely demonstrated that neuroinflammation plays a critical role in the development of …
widely demonstrated that neuroinflammation plays a critical role in the development of …
Nociceptive neurons detect cytokines in arthritis
HG Schaible - Arthritis research & therapy, 2014 - Springer
Proinflammatory cytokines are major mediators in the pathogenesis of diseases of joints
such as rheumatoid arthritis and osteoarthritis. This review emphasizes that proinflammatory …
such as rheumatoid arthritis and osteoarthritis. This review emphasizes that proinflammatory …
Osteoarthritis joint pain: the cytokine connection
Osteoarthritis is a chronic and painful disease of synovial joints. Chondrocytes, synovial
cells and other cells in the joint can express and respond to cytokines and chemokines, and …
cells and other cells in the joint can express and respond to cytokines and chemokines, and …
Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis
EHS Choy, LH Calabrese - Rheumatology, 2018 - academic.oup.com
RA is a chronic, systemic, autoimmune disease characterized by inflammation and
degradation of the joints, causing significant negative impact on quality of life. In addition to …
degradation of the joints, causing significant negative impact on quality of life. In addition to …
Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain
Background: Despite advances in our understanding of basic mechanisms driving post-
surgical pain, treating incision-induced pain remains a major clinical challenge. Moreover …
surgical pain, treating incision-induced pain remains a major clinical challenge. Moreover …
3D biomaterial matrix to support long term, full thickness, immuno-competent human skin equivalents with nervous system components
SEL Vidal, KA Tamamoto, H Nguyen, RD Abbott… - Biomaterials, 2019 - Elsevier
Current commercially available human skin equivalents (HSEs) are used for relatively short
term studies (∼ 1 week) due in part to the time-dependent contraction of the collagen gel …
term studies (∼ 1 week) due in part to the time-dependent contraction of the collagen gel …
Understanding the initiation, delivery and processing of bone cancer pain from the peripheral to the central nervous system
L Yang, B Liu, S Zheng, L Xu, M Yao - Neuropharmacology, 2023 - Elsevier
Bone cancer pain is a complex condition characterized by persistent, sudden, spontaneous
pain accompanied by hyperalgesia that typically arises from bone metastases or primary …
pain accompanied by hyperalgesia that typically arises from bone metastases or primary …
Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression
Glycoprotein 130 (gp130) is the signal transducing receptor subunit for cytokines of the
interleukin-6 (IL-6) family, and it is expressed in a multitude of cell types of the immune and …
interleukin-6 (IL-6) family, and it is expressed in a multitude of cell types of the immune and …
microRNAs in nociceptive circuits as predictors of future clinical applications
Neuro-immune alterations in the peripheral and central nervous system play a role in the
pathophysiology of chronic pain, and non-coding RNAs (ncRNAs)–and microRNAs …
pathophysiology of chronic pain, and non-coding RNAs (ncRNAs)–and microRNAs …