[HTML][HTML] Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer
L Yang, HJ Xie, YY Li, X Wang, XX Liu… - Oncology …, 2022 - spandidos-publications.com
Cisplatin is one of the most effective chemotherapy drugs for ovarian cancer, but resistance
is common. The initial response to platinum‑based chemotherapy is as high as 80%, but in …
is common. The initial response to platinum‑based chemotherapy is as high as 80%, but in …
Immunohistochemical biomarkers as a surrogate of molecular analysis in ovarian carcinomas: a review of the literature
G Santandrea, S Piana, R Valli, M Zanelli, E Gasparini… - Diagnostics, 2021 - mdpi.com
The term “ovarian carcinoma” encompasses at least five different malignant neoplasms: high-
grade serous carcinoma, low-grade serous carcinoma, endometrioid carcinoma, mucinous …
grade serous carcinoma, low-grade serous carcinoma, endometrioid carcinoma, mucinous …
[HTML][HTML] Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis
Germline pathogenic mutations in BReast CAncer (BRCA1) genes are thought to drive
normal fallopian tube epithelial (FTE) cell transformation to high-grade serous ovarian …
normal fallopian tube epithelial (FTE) cell transformation to high-grade serous ovarian …
Early genetic divergence of high-grade carcinomas originating from low-grade serous ovarian neoplasms
The current paradigm implicates a fallopian tube precursor as the origin of most ovarian high-
grade serous carcinomas (HGSCs). However, a rare subset of HGSCs develop via a distinct …
grade serous carcinomas (HGSCs). However, a rare subset of HGSCs develop via a distinct …
A comprehensive immunohistochemical analysis of 26 markers in 250 cases of serous ovarian tumors
K Němejcová, A Šafanda, MK Bártů, R Michálková… - Diagnostic …, 2023 - Springer
Background We examined a large cohort of serous tubo-ovarian tumors with 26
immunohistochemical markers, with the aim to assess their value for differential diagnosis …
immunohistochemical markers, with the aim to assess their value for differential diagnosis …
Mutated p53 in hgsc—from a common mutation to a target for therapy
A Saleh, R Perets - Cancers, 2021 - mdpi.com
Simple Summary Ovarian high-grade serous cancer (HGSC), the most common and the
deadliest subtype of epithelial ovarian cancer, is characterized by frequent mutations in the …
deadliest subtype of epithelial ovarian cancer, is characterized by frequent mutations in the …
P53 long noncoding RNA regulatory network in cancer development
The protein p53 as a transcription factor with strong tumor‐suppressive activities is known to
trigger apoptosis via multiple pathways and is directly involved in the recognition of DNA …
trigger apoptosis via multiple pathways and is directly involved in the recognition of DNA …
The many faces of serous neoplasms and related lesions of the female pelvis: a review
Ovarian serous tumors and related lesions are one of the most common conditions of the
female genital tract. While ovarian high-grade serous carcinoma carries high mortality and …
female genital tract. While ovarian high-grade serous carcinoma carries high mortality and …
Diagnostic roles of PAX8 immunohistochemistry in ovarian tumors
J Kim, NY Kim, JS Pyo, KW Min, DW Kang - Pathology-Research and …, 2023 - Elsevier
Objective This study aimed to elucidate the diagnostic roles of PAX8 immunohistochemistry
in various ovarian tumors. Methods We searched through the PubMed database and …
in various ovarian tumors. Methods We searched through the PubMed database and …
[HTML][HTML] PTEN Deficiency in Tubo-Ovarian High-Grade Serous Carcinoma is Associated with Poor Progression-Free Survival and is Mutually Exclusive with CCNE1 …
As a critical tumor suppressor, PTEN has gained much attention in cancer research.
Emerging evidence suggests an association between PTEN status and clinical outcome in …
Emerging evidence suggests an association between PTEN status and clinical outcome in …