From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses

Z Zhu, X Lian, X Su, W Wu, GA Marraro, Y Zeng - Respiratory research, 2020 - Springer
Within two decades, there have emerged three highly pathogenic and deadly human
coronaviruses, namely SARS-CoV, MERS-CoV and SARS-CoV-2. The economic burden …

Coronaviruses—drug discovery and therapeutic options

A Zumla, JFW Chan, EI Azhar, DSC Hui… - Nature reviews Drug …, 2016 - nature.com
In humans, infections with the human coronavirus (HCoV) strains HCoV-229E, HCoV-OC43,
HCoV-NL63 and HCoV-HKU1 usually result in mild, self-limiting upper respiratory tract …

SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo

KPY Hui, JCW Ho, M Cheung, K Ng, RHH Ching, K Lai… - Nature, 2022 - nature.com
The emergence of SARS-CoV-2 variants of concern with progressively increased
transmissibility between humans is a threat to global public health. The Omicron variant of …

Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection

J Luan, Y Lu, X Jin, L Zhang - Biochemical and biophysical research …, 2020 - Elsevier
SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the
receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS …

The recent challenges of highly contagious COVID‐19, causing respiratory infections: Symptoms, diagnosis, transmission, possible vaccines, animal models, and …

RK Mohapatra, L Pintilie, V Kandi… - Chemical biology & …, 2020 - Wiley Online Library
COVID‐19 is highly contagious pathogenic viral infection initiated from Wuhan seafood
wholesale market of China on December 2019 and spread rapidly around the whole world …

Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease

JFW Chan, SKP Lau, KKW To… - Clinical microbiology …, 2015 - Am Soc Microbiol
The source of the severe acute respiratory syndrome (SARS) epidemic was traced to wildlife
market civets and ultimately to bats. Subsequent hunting for novel coronaviruses (CoVs) led …

Bat-to-human: spike features determining 'host jump'of coronaviruses SARS-CoV, MERS-CoV, and beyond

G Lu, Q Wang, GF Gao - Trends in microbiology, 2015 - cell.com
Both severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East
respiratory syndrome coronavirus (MERS-CoV) are zoonotic pathogens that crossed the …

[HTML][HTML] Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United …

DL Ng, F Al Hosani, MK Keating, SI Gerber… - The American journal of …, 2016 - Elsevier
Middle East respiratory syndrome coronavirus (MERS-CoV) infection causes an acute
respiratory illness and is associated with a high case fatality rate; however, the pathogenesis …

Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia

JSM Sabir, TTY Lam, MMM Ahmed, L Li, Y Shen… - Science, 2016 - science.org
Outbreaks of Middle East respiratory syndrome (MERS) raise questions about the
prevalence and evolution of the MERS coronavirus (CoV) in its animal reservoir. Our …

Broad-spectrum coronavirus antiviral drug discovery

AL Totura, S Bavari - Expert opinion on drug discovery, 2019 - Taylor & Francis
Introduction: The highly pathogenic coronaviruses severe acute respiratory syndrome
coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) …