Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing,
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …

The origins and importance of spliceosomal introns comprise one of the longest-abiding
mysteries of molecular evolution. Considerable debate remains over several aspects of the …

During evolution, there have been several major changes in the way that genetic information
is organized and transmitted from one generation to the next. These transitions include the …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

Eukaryotic phenotypic diversity arises from multitasking of a core proteome of limited size.
Multitasking is routine in computers, as well as in other sophisticated information systems …

The origin of the eukaryotic nucleus marked a seminal evolutionary transition. We propose
that the nuclear envelope's incipient function was to allow mRNA splicing, which is slow, to …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

▪ Abstract Genome sequencing and structural genomics projects are providing new insights
into the evolutionary history ofprote in domains. As methods for sequence and structure …

FIG. 1. Some keyevents in the evolution ofhemoglobingenes. Three different phasesare
shown at increasing levels of resolution. The top three lines indicate that several …

The evolution of complex genomes requires that new combinations of pre-existing protein
domains successfully fold into modular polypeptides. During eukaryotic translation model …