Aminoacyl-tRNA synthetases
MAR Gomez, M Ibba - Rna, 2020 - rnajournal.cshlp.org
The aminoacyl-tRNA synthetases are an essential and universally distributed family of
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …
Synthetic and editing mechanisms of aminoacyl-tRNA synthetases
JJ Perona, I Gruic-Sovulj - Aminoacyl-tRNA synthetases in biology and …, 2014 - Springer
Aminoacyl-tRNA synthetases (aaRS) ensure the faithful transmission of genetic information
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …
Free energy landscape of the adenylation reaction of the aminoacylation process at the active site of aspartyl tRNA synthetase
S Dutta, A Chandra - The Journal of Physical Chemistry B, 2022 - ACS Publications
The process of protein biosynthesis is initiated by the aminoacylation process where a
transfer ribonucleic acid (tRNA) is charged by the attachment of its cognate amino acid at the …
transfer ribonucleic acid (tRNA) is charged by the attachment of its cognate amino acid at the …
Establishing a substrate-assisted mechanism for the pre-transfer editing in SerRS and IleRS: A QM/QM investigation
MM Aboelnga, JW Gauld - Structural Chemistry, 2024 - Springer
Aminoacyl-tRNA synthetases (aaRS) are key enzymes in protein biosynthesis that employ
various editing mechanisms to ensure faithful translation of genetic information. Seryl-tRNA …
various editing mechanisms to ensure faithful translation of genetic information. Seryl-tRNA …
Universal codons with enrichment from GC to AU nucleotide composition reveal a chronological assignment from early to late along with LUCA formation
A Gospodinov, D Kunnev - Life, 2020 - mdpi.com
The emergence of a primitive genetic code should be considered the most essential event
during the origin of life. Almost a complete set of codons (as we know them) should have …
during the origin of life. Almost a complete set of codons (as we know them) should have …
Backbone brackets and arginine tweezers delineate class I and class II aminoacyl tRNA synthetases
F Kaiser, S Bittrich, S Salentin… - PLoS computational …, 2018 - journals.plos.org
The origin of the machinery that realizes protein biosynthesis in all organisms is still unclear.
One key component of this machinery are aminoacyl tRNA synthetases (aaRS), which ligate …
One key component of this machinery are aminoacyl tRNA synthetases (aaRS), which ligate …
Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip
L Pang, V Zanki, SV Strelkov, A Van Aerschot… - Communications …, 2022 - nature.com
To correctly aminoacylate tRNALeu, leucyl-tRNA synthetase (LeuRS) catalyzes three
reactions: activation of leucine by ATP to form leucyl-adenylate (Leu-AMP), transfer of this …
reactions: activation of leucine by ATP to form leucyl-adenylate (Leu-AMP), transfer of this …
Placental, Foetal, and Maternal Serum Metabolomic Profiles in Pregnancy-Associated Cancer: Walker-256 Tumour Model in a Time-Course Analysis
C De Moraes Salgado, LR Viana… - International Journal of …, 2023 - mdpi.com
Cancer during pregnancy presents a delicate coexistence, imposing ethical and
professional challenges on both the patient and medical team. In this study, we aimed to …
professional challenges on both the patient and medical team. In this study, we aimed to …
Clinical and genetic analyses of premature mitochondrial encephalopathy with epilepsia partialis continua caused by novel biallelic NARS2 mutations
W Hu, H Fang, Y Peng, L Li, D Guo, J Tang… - Frontiers in …, 2022 - frontiersin.org
Biallelic NARS2 mutations can cause various neurodegenerative diseases, leading to
growth retardation, intractable epilepsy, and hearing loss in early infancy and further …
growth retardation, intractable epilepsy, and hearing loss in early infancy and further …
A water-mediated and substrate-assisted aminoacylation mechanism in the discriminating aminoacyl-tRNA synthetase GlnRS and non-discriminating GluRS
MM Aboelnga, JJ Hayward, JW Gauld - Physical Chemistry Chemical …, 2017 - pubs.rsc.org
Glutaminyl-tRNA synthetase (GlnRS) catalyzes the aminoacylation of glutamine to the
corresponding tRNAGln. However, most bacteria and all archaea lack GlnRS and thus an …
corresponding tRNAGln. However, most bacteria and all archaea lack GlnRS and thus an …