Delivery of cancer therapies by synthetic and bio-inspired nanovectors

T Briolay, T Petithomme, M Fouet, N Nguyen-Pham… - Molecular cancer, 2021 - Springer
Background As a complement to the clinical development of new anticancer molecules,
innovations in therapeutic vectorization aim at solving issues related to tumor specificity and …

[HTML][HTML] A comprehensive review on phage therapy and phage-based drug development

L Cui, S Watanabe, K Miyanaga, K Kiga, T Sasahara… - Antibiotics, 2024 - mdpi.com
Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining
momentum as a promising weapon against the rising threat of multidrug-resistant (MDR) …

Exploiting gut bacteriophages for human health

M Dalmasso, C Hill, RP Ross - Trends in microbiology, 2014 - cell.com
The human gut contains approximately 10 15 bacteriophages (the 'phageome'), probably
the richest concentration of biological entities on earth. Mining and exploiting these potential …

NK cell–derived exosomes from NK cells previously exposed to neuroblastoma cells augment the antitumor activity of cytokine-activated NK cells

A Shoae-Hassani, AA Hamidieh, M Behfar… - Journal of …, 2017 - journals.lww.com
Immune cell–derived exosomes can increase immunity against tumors. In contrast, tumor-
derived exosomes can reduce the immunity and can change the tumor microenvironment to …

Bioinspired gold coated phage nanosomes for anti-microbial and anti-cancer theranostics

DN Yadav, SA Sankaranarayanan, AM Thanekar… - Materials Today …, 2023 - Elsevier
We report a unique bioinspired phage nanosome as a biological template for tuning the NIR
absorbance of gold nanoparticles (Ф NS Au) coated on its surface. Spectroscopical analysis …

Apoptin as a tumor-specific therapeutic agent: current perspective on mechanism of action and delivery systems

WA Malla, R Arora, RIN Khan, S Mahajan… - Frontiers in cell and …, 2020 - frontiersin.org
Cancer remains one of the leading causes of death worldwide in humans and animals.
Conventional treatment regimens often fail to produce the desired outcome due to …

The landscape of nanovectors for modulation in cancer immunotherapy

SR Volovat, CL Ursulescu, LG Moisii, C Volovat… - Pharmaceutics, 2022 - mdpi.com
Immunotherapy represents a promising strategy for the treatment of cancer, which functions
via the reprogramming and activation of antitumor immunity. However, adverse events …

Natural killer cells from the subcutaneous adipose tissue underexpress the NKp30 and NKp44 in obese persons and are less active against major histocompatibility …

A Shoae-Hassani, M Behfar… - Frontiers in …, 2017 - frontiersin.org
There are many types of leukocytes reside in subcutaneous adipose tissue (SAT), and
among them, natural killer cells (NKs) comprise a major part. We show that the NKs that …

Phage peptide libraries as a source of targeted ligands

AA Nemudraya, VA Richter… - Acta Naturae …, 2016 - cyberleninka.ru
One of the dominant trends in modern pharmacology is the creation of drugs that act directly
on the lesion focus and have minimal toxicity on healthy tissues and organs. This problem is …

Controllable degradation kinetics of POSS nanoparticle-integrated poly (ε-caprolactone urea) urethane elastomers for tissue engineering applications

L Yildirimer, A Buanz, S Gaisford, EL Malins… - Scientific reports, 2015 - nature.com
Biodegradable elastomers are a popular choice for tissue engineering scaffolds, particularly
in mechanically challenging settings (eg the skin). As the optimal rate of scaffold …