Abstract Type 1 diabetes (T1D) is due to antigen-specific assaults on the insulin producing
pancreatic β-cells by diabetogenic T-helper (Th) 1 cells.(CXC motif) ligand (CXCL) 10, an …

As therapeutic options for multiple sclerosis widen, validated biomarkers of clinical disease
activity are urgently needed. Reliable biomarkers would assist in choosing initial therapy …

BACKGROUND: T regulatory (Treg) cells are characterized by expression of suppressive
cytokines and the transcription factor FOXP3. They play a key role in balancing immune …

Abstract Thymus-derived CD4+ CD25+ regulatory T (Treg) cells are essential for the
maintenance of immunologic self-tolerance. Despite their critical role in the active …

Autoimmune diseases such as multiple sclerosis (MS) may result from the failure of
tolerance mechanisms to prevent expansion of pathogenic T cells. Our study is the first to …

Pathogen persistence after clinical cure is a hallmark of many chronic infections. Previously,
we showed that naturally occurring CD4+ CD25+ regulatory T (nTreg) cells rapidly …

In the autoimmune disease multiple sclerosis and its animal model, experimental
autoimmune encephalomyelitis (EAE), expansion of pathogenic, myelin-specific Th1 cell …

Interferon beta-1a (IFNâ-1a) has demonstrated efficacy in multiple sclerosis (MS), although
its mechanism of action remains only partly understood. We evaluated the ex vivo and in …

Objectives: The forkhead family transcription factor Foxp3 currently represents the most
specific marker molecule for CD4+ CD25+ T cells with suppressive/regulatory capacity …

Pregnancy represents a physiological transitory state of immune tolerance to avoid the
rejection of the foetus, and concomitantly of stabilisation of many autoimmune diseases …