Mechanisms involved in epileptogenesis in Alzheimer's disease and their therapeutic implications
M Altuna, G Olmedo-Saura, M Carmona-Iragui… - International journal of …, 2022 - mdpi.com
Epilepsy and Alzheimer's disease (AD) incidence increases with age. There are reciprocal
relationships between epilepsy and AD. Epilepsy is a risk factor for AD and, in turn, AD is an …
relationships between epilepsy and AD. Epilepsy is a risk factor for AD and, in turn, AD is an …
Ion channel dysfunction in astrocytes in neurodegenerative diseases
S Wang, B Wang, D Shang, K Zhang, X Yan… - Frontiers in …, 2022 - frontiersin.org
Astrocytes play an important role in the central nervous system (CNS). Ion channels in these
cells not only function in ion transport, and maintain water/ion metabolism homeostasis, but …
cells not only function in ion transport, and maintain water/ion metabolism homeostasis, but …
Treatment of epilepsy using a targeted p38γ kinase gene therapy
N Morey, M Przybyla, J van der Hoven, YD Ke… - Science …, 2022 - science.org
Hyperphosphorylated microtubule-associated protein tau has been implicated in dementia,
epilepsy, and other neurological disorders. In contrast, site-specific phosphorylation of tau at …
epilepsy, and other neurological disorders. In contrast, site-specific phosphorylation of tau at …
Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression
Mutations in PCDH19 gene, which encodes protocadherin-19 (PCDH19), cause
Developmental and Epileptic Encephalopathy 9 (DEE9). Heterogeneous loss of PCDH19 …
Developmental and Epileptic Encephalopathy 9 (DEE9). Heterogeneous loss of PCDH19 …
Development of small-molecule Tau-SH3 interaction inhibitors that prevent amyloid-β toxicity and network hyperexcitability
JR Roth, T Rush, SJ Thompson, AR Aldaher, TB Dunn… - …, 2024 - Elsevier
Alzheimer's disease (AD) is the leading cause of dementia and lacks highly effective
treatments. Tau-based therapies hold promise. Tau reduction prevents amyloid-β–induced …
treatments. Tau-based therapies hold promise. Tau reduction prevents amyloid-β–induced …
Saracatinib, a Src tyrosine kinase inhibitor, as a disease modifier in the rat DFP model: sex differences, Neurobehavior, gliosis, neurodegeneration, and nitro-oxidative …
M Gage, M Putra, L Wachter, K Dishman, M Gard… - Antioxidants, 2021 - mdpi.com
Diisopropylfluorophosphate (DFP), an organophosphate nerve agent (OPNA), exposure
causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective …
causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective …
Latest advances in mechanisms of epileptic activity in Alzheimer's disease and dementia with Lewy Bodies
M Vicente, K Addo-Osafo, K Vossel - Frontiers in neurology, 2024 - frontiersin.org
Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) stand as the prevailing
sources of neurodegenerative dementia, impacting over 55 million individuals across the …
sources of neurodegenerative dementia, impacting over 55 million individuals across the …
Peptide aptamer targeting Aβ–PrP–Fyn axis reduces Alzheimer's disease pathologies in 5XFAD transgenic mouse model
T Ali, AN Klein, A Vu, MI Arifin, S Hannaoui… - Cellular and Molecular …, 2023 - Springer
Currently, no effective therapeutics exist for the treatment of incurable neurodegenerative
diseases such as Alzheimer's disease (AD). The cellular prion protein (PrPC) acts as a high …
diseases such as Alzheimer's disease (AD). The cellular prion protein (PrPC) acts as a high …
Enhanced Fyn-tau and NR2B-PSD95 interactions in epileptic foci in experimental models and human epilepsy
Epilepsy and Alzheimer's disease share some common pathologies such as
neurodegeneration, seizures and impaired cognition. However, the molecular mechanisms …
neurodegeneration, seizures and impaired cognition. However, the molecular mechanisms …
Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy
S Sharma, S Carlson, A Gregory-Flores… - Neurobiology of …, 2021 - Elsevier
We have recently demonstrated the role of the Fyn-PKCδ signaling pathway in status
epilepticus (SE)-induced neuroinflammation and epileptogenesis in experimental models of …
epilepticus (SE)-induced neuroinflammation and epileptogenesis in experimental models of …