Proteins are the main targets of most drugs; however, system-wide methods to monitor
protein activity and function are still underused in drug discovery. Novel biochemical …

The ability to identify ovarian cancer (OC) at its earliest stages remains a challenge. The
patients present an advanced stage at diagnosis. This heterogeneous disease has …

Protein networks have become a popular tool for analyzing and visualizing the often long
lists of proteins or genes obtained from proteomics and other high-throughput technologies …

High-grade serous carcinoma has a poor prognosis, owing primarily to its early
dissemination throughout the abdominal cavity. Genomic and proteomic approaches have …

Biological networks are often used to represent complex biological systems, which can
contain several types of entities. Analysis and visualization of such networks is supported by …

Molecular alterations in cancer genes and associated signaling pathways are used to inform
new treatments for precision medicine in cancer. Small molecule inhibitors and monoclonal …

Protein phosphorylation is a major regulator of protein function and biological outcomes.
This was first recognized through functional biochemical experiments, and in the past …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

Acute myeloid leukemia (AML) is a heterogeneous disease with variable patient responses
to therapy. Selinexor, an inhibitor of nuclear export, has shown promising clinical activity for …

The poor prognosis of ovarian cancer is mainly due to metastasis, and the specific
mechanism underlying ovarian cancer metastasis is not clear. Ascites-derived exosomes …