Alcohol-associated liver disease: natural history, management and novel targeted therapies

E Alvarado-Tapias, E Pose, J Gratacós… - Clinical and Molecular …, 2024 - e-cmh.org
Alcohol consumption is a leading cause of preventable morbidity and mortality worldwide
and the primary cause of advanced liver disease. Alcohol use disorder (AUD) is a chronic …

Emerging drugs in phase II and III clinical development for the treatment of alcohol use disorder

S Köhne, T Hillemacher, A Glahn… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction Alcohol Use Disorder (AUD) poses an ongoing significant global
health burden. AUD is highly prevalent and affects not only the individuals with AUD, but …

Le baclofène à fortes doses dans le trouble de l'usage de l'alcool 20 ans après

B Granger - Bulletin de l'Académie Nationale de Médecine, 2024 - Elsevier
Résumé En 2004 paraissait une auto-observation d'un cardiologue français soulignant
l'intérêt du baclofène à hautes doses dans le trouble de l'usage de l'alcool. L'intérêt …

[PDF][PDF] Substitution therapy for patients with alcohol dependence: Mechanisms of action and efficacy

J Guiraud, R Spanagel… - International review of …, 2024 - researchgate.net
New approaches for the treatment of alcohol dependence (AD) may improve patient
outcomes. Substitution maintenance therapy is one of the most effective treatment options …

Drug-induced Liver Injury Due to Medications for Alcohol Use Disorder: Results From the DILIN Prospective Study

H Gopalakrishna, M Ghabril, J Gu, YJ Li… - Journal of Addiction …, 2024 - journals.lww.com
Objectives Concerns about drug-induced liver injury (DILI) may deter physicians from
prescribing medications for alcohol use disorder (MAUD). We aim to explore DILI due to …

Baclofen for the Treatment of Alcohol Use Disorder

R Agabio, B Rolland, L Leggio - GABAB Receptor, 2024 - Springer
Baclofen is the only GABA type-B (GABAB) receptor agonist available for use in clinical
practice; it has been approved worldwide for the treatment of spasticity for more than 50 …

Baclofen Safety, Toxicity, Withdrawal, and Overdose

JW Romito, BT Romito - GABAB Receptor, 2024 - Springer
Baclofen is a proven and effective agent for the management of spasticity. Its use has
recently expanded to the off-label treatment of several other diseases. It is important for …

アルコール関連肝疾患のトピックス

今一義 - 日本消化器病学会雑誌, 2024 - jstage.jst.go.jp
抄録 本邦で行われた 2023 年の集計で, アルコール関連肝疾患は肝硬変の成因の第 1
位となった. 2023 年 6 月に発表された steatotic liver disease (SLD) の概念ではアルコール関連 …