Heart failure and related morbidity and mortality are increasing at an alarming rate, in large
part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes …

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Diabetic cardiomyopathy is characterised in its early stages by diastolic relaxation
abnormalities and later by clinical heart failure in the absence of dyslipidaemia …

Insulin resistance, type 2 diabetes mellitus and associated hyperinsulinaemia can promote
the development of a specific form of cardiomyopathy that is independent of coronary artery …

Individuals with diabetes mellitus (DM) disclose a higher incidence and a poorer prognosis
of heart failure (HF) than non-diabetic people, even in the absence of other HF risk factors …

Insights from epidemiological, clinical and basic research are illuminating the interplay
between metabolic disorders, cardiovascular disease (CVD) and kidney dysfunction, termed …

Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly
refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults …

The high incidence and poor prognosis of heart failure (HF) patients affected with diabetes
(DM) is in part related to a specific cardiac remodeling currently recognized as diabetic …

Heart failure (HF) is a major cause of morbidity and mortality in the Western world. HF is
present in more than 5 million people in the United States, accounting for nearly US $40 …

Insulin resistance is a hallmark of obesity, the cardiorenal metabolic syndrome and type 2
diabetes mellitus (T2DM). The progression of insulin resistance increases the risk for …