DNA methylation profiles in cancer diagnosis and therapeutics

Y Pan, G Liu, F Zhou, B Su, Y Li - Clinical and experimental medicine, 2018 - Springer
Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer

P Li, S Liu, L Du, G Mohseni, Y Zhang, C Wang - Clinical epigenetics, 2022 - Springer
Lung cancer (LC) is the main cause of cancer-related mortality. Most LC patients are
diagnosed in an advanced stage when the symptoms are obvious, and the prognosis is …

Lung cancer epigenetics: from knowledge to applications

M Duruisseaux, M Esteller - Seminars in cancer biology, 2018 - Elsevier
Lung cancer is the leading cause of cancer-related mortality worldwide. Advances in our
understanding of the genomics of lung cancer have led to substantial progress in the …

DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types

V Constâncio, SP Nunes, R Henrique, C Jerónimo - Cells, 2020 - mdpi.com
Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

Circulating tumor cells: from new biological insights to clinical practice

X Gu, S Wei, X Lv - Signal Transduction and Targeted Therapy, 2024 - nature.com
The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …

[HTML][HTML] SCLC: epidemiology, risk factors, genetic susceptibility, molecular pathology, screening, and early detection

Q Wang, ZH Gümüş, C Colarossi, L Memeo… - Journal of Thoracic …, 2023 - Elsevier
We review research regarding the epidemiology, risk factors, genetic susceptibility,
molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of …

DNA methylation biomarkers: cancer and beyond

T Mikeska, JM Craig - Genes, 2014 - mdpi.com
Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

CL Relton, G Davey Smith - International journal of …, 2012 - academic.oup.com
The burgeoning interest in the field of epigenetics has precipitated the need to develop
approaches to strengthen causal inference when considering the role of epigenetic …

Potential clinical utility of liquid biopsy in early-stage non-small cell lung cancer

H Shen, Y Jin, H Zhao, M Wu, K Zhang, Z Wei, X Wang… - BMC medicine, 2022 - Springer
Background Liquid biopsy has been widely researched for early diagnosis, prognostication
and disease monitoring in lung cancer, but there is a need to investigate its clinical utility for …

Diagnostic and prognostic epigenetic biomarkers in cancer

P Costa-Pinheiro, D Montezuma, R Henrique… - …, 2015 - Taylor & Francis
Growing cancer incidence and mortality worldwide demands development of accurate
biomarkers to perfect detection, diagnosis, prognostication and monitoring. Urologic …