By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging
(MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary …

The sensitivity of conventional nuclear magnetic resonance (NMR) techniques is
fundamentally limited by the ordinarily low spin polarization achievable in even the strongest …

The nuclear spin polarization of the noble gas isotopes 3He and 129Xe can be increased
using optical pumping methods by four to five orders of magnitude. This extraordinary gain …

Using a new method of xenon laser‐polarization that permits the generation of liter
quantities of hyperpolarized 129Xe gas, the first 129Xe imaging results from the human …

Purpose To develop a breathhold acquisition for regional mapping of ventilation and the
fractions of hyperpolarized xenon‐129 (Xe129) dissolved in tissue (lung parenchyma and …

Despite a myriad of technical advances in medical imaging, as well as the growing need to
address the global impact of pulmonary diseases, such as asthma and chronic obstructive …

Lung imaging has traditionally relied on x‐ray methods, since proton MRI is limited to some
extent by low proton density in the lung parenchyma and static field inhomogeneities in the …

Hyperpolarised gas lung MRI using xenon-129 can provide detailed 3D images of the
ventilated lung airspaces, and can be applied to quantify lung microstructure and detailed …

MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this
modality has limited the clinical use to imaging of water protons. With hyperpolarization …

One of the major goals of hyperpolarized‐gas MRI has been to obtain 129Xe dissolved‐
phase images in humans. So far, this goal has remained elusive, mainly due to the low …