Antimicrobial resistance represents an enormous global health crisis and one of the most
serious threats humans face today. Some bacterial strains have acquired resistance to …

The discovery of antibiotics has created a turning point in medical interventions to
pathogenic infections, but unfortunately, each discovery was consistently followed by the …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Macromolecular crowding affects the activity of proteins and functional macromolecular
complexes in all cells, including bacteria. Crowding, together with physicochemical …

During the life cycle of the filamentous bacteria Streptomyces, morphological differentiation
is closely integrated with fundamental growth and cell-cycle processes, as well as with truly …

If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long,
approximately 1,000 times the length of a cell. Not only must cells massively compact their …

The importance of the cell wall to the viability of the bacterium is underscored by the breadth
of antibiotic structures that act by blocking key enzymes that are tasked with cell-wall …

Many studies have focused on the mechanisms underlying length and width determination
in rod-shaped bacteria. Here, we focus instead on cell surface area to volume ratio (SA/V) …

The ability to detect single molecules in live bacterial cells enables us to probe biological
events one molecule at a time and thereby gain knowledge of the activities of intracellular …

The positioning of a cytoskeletal element that dictates the division plane is a fundamental
problem in biology. The assembly and positioning of this cytoskeletal element has to be …