Abstract Exportin 1 (XPO1), also known as chromosome region maintenance protein 1,
plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of …

Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma that is most
commonly treated with combination chemo-immunotherapy at diagnosis because of the …

Mantle cell lymphoma (MCL) is a well-defined lymphoid malignancy characterized by a
rapid clinical evolution and poor response to current therapeutic protocols. The genetic and …

Mantle-cell lymphoma (MCL) is a mature B-cell lymphoma with an aggressive course and
generally poor prognosis. Conventional chemotherapy has little efficacy. Bortezomib is a …

Apoptosis is a crucial biological process that prevents uncontrolled cell proliferation and
eliminates harmful cells. Resistance to apoptotic stimuli is a hallmark feature of various …

The mechanisms driving therapeutic resistance and poor outcomes of mantle cell lymphoma
(MCL) are incompletely understood. We characterize the cellular and molecular …

Survivin is a member of the inhibitor of apoptosis protein (IAP) family, that has been
implicated in both control of cell division and inhibition of apoptosis. Specifically, its anti …

Growing evidence suggests that survivin expression in cancer cell nuclei may represent an
important prognostic marker to predict disease outcome for cancer patients. Current reports …

Background Ki-67 is a nuclear protein involved in cell proliferation regulation, and its
expression has been widely used as an index to evaluate the proliferative activity of …

Background: Results in previous qualitative studies of the association of the apoptosis
inhibitor survivin with prognosis of breast cancer patients have been contradictory. Methods …