The predominantly animal-centric approach of chemical safety assessment has increasingly
come under pressure. Society is questioning overall performance, sustainability, continued …

Risk assessment of cosmetic ingredients is a useful scientific method to characterize
potential adverse effects resulting from using cosmetics. The process of risk assessment …

Current approaches for the assessment of environmental and human health risks due to
exposure to chemical substances have served their purpose reasonably well. Nevertheless …

In the current time, the number of various engineered nanomaterials (NMs) and
nanoparticles (NPs) is increasing at a steady pace due to the new developments in the field …

This paper presents a 10-step read-across (RAX) framework for use in cases where a
threshold of toxicological concern (TTC) approach to cosmetics safety assessment is not …

While whole animal studies have their place in risk assessment of food and feed
components, it is thought that more modern approaches such as human focused new …

Read-across (RAx) translates available information from well-characterized chemicals to a
substance for which there is a toxicological data gap. The OECD is working on case studies …

In many industrial sectors, there is a need for reliable ways to evaluate the safety of
chemicals with methods anchored to human biology and pathology. For this purpose, many …

Rodent cancer bioassays have been long-required studies for regulatory assessment of
human cancer hazard and risk. These studies use hundreds of animals, are resource …

For almost fifteen years, the availability and regulatory acceptance of new approach
methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion …