Beneficial health effects of glucosinolates-derived isothiocyanates on cardiovascular and neurodegenerative diseases

RM Kamal, AF Abdull Razis, NS Mohd Sukri… - Molecules, 2022 - mdpi.com
Neurodegenerative diseases (NDDs) and cardiovascular diseases (CVDs) are illnesses that
affect the nervous system and heart, all of which are vital to the human body. To maintain …

Pesticides and Parkinson's disease: Current and future perspective

MS Islam, F Azim, H Saju, A Zargaran, M Shirzad… - Journal of Chemical …, 2021 - Elsevier
Inappropriate use of pesticides has globally exposed mankind to a number of health
hazards. Still their production is rising at the rate of 11% annually and, has already …

Medicinal perspective of indole derivatives: recent developments and structure-activity relationship studies

D Kumar, S Sharma, S Kalra, G Singh… - Current drug …, 2020 - ingentaconnect.com
Heterocyclic compounds play a significant role in various biological processes of the human
body and many of them are in clinical use due to their diverse, chemical and biological …

[HTML][HTML] Research progress of natural products for the treatment of ischemic stroke

J Li, T Zhao, H Qiao, Y Li, M Xia, X Wang… - Journal of Integrative …, 2022 - imrpress.com
Stroke is a leading cause of death and disability world-widely. The incidence rate of stroke
has been increasing due to the aging population and lifestyle changes. At present, the only …

Indole-3-carbinol regulates microglia homeostasis and protects the retina from degeneration

AS Khan, T Langmann - Journal of Neuroinflammation, 2020 - Springer
Background Retinal degenerative diseases significantly contribute to visual impairment and
blindness. Microglia reactivity is a hallmark of neurodegenerative diseases including retinal …

Safranal protects against ischemia-induced PC12 cell injury through inhibiting oxidative stress and apoptosis

F Forouzanfar, E Asadpour, H Hosseinzadeh… - Naunyn-Schmiedeberg's …, 2021 - Springer
Safranal, isolated from saffron (Crocus sativus L.), is known to possesses neuroprotective
effects. In this study, the neuroprotective potential of safranal against PC12 cell injury …

Protective effect of Indole-3-carbinol, an NF-κB inhibitor in experimental paradigm of Parkinson's disease: in silico and in vivo studies

N Saini, A Akhtar, M Chauhan, N Dhingra… - Brain, Behavior, and …, 2020 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder, majorly with
symptoms of motor dysfunction. Study was performed to explore the effect of nuclear factor …

[HTML][HTML] Dihydroquercetin ameliorates LPS-induced neuroinflammation and memory deficit

Q Alam, S Krishnamurthy - Current Research in Pharmacology and Drug …, 2022 - Elsevier
Dihydroquercetin (DHQ) is a pentahydroxyflavanone that has been used as an important
suppliment against oxidative stress related inflammation and neuroinflammation …

Impacts of commonly used edible plants on the modulation of platelet function

DAI Albadawi, D Ravishankar, TM Vallance… - International Journal of …, 2022 - mdpi.com
Cardiovascular diseases (CVDs) are a primary cause of deaths worldwide. Thrombotic
diseases, specifically stroke and coronary heart diseases, account for around 85% of CVDs …

[HTML][HTML] Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin

C Qian, C Yang, M Lu, J Bao, H Shen, B Deng, S Li… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Neprilysin (NEP) is a major endogenous catabolic enzyme of amyloid β (Aβ).
Previous studies have suggested that increasing NEP expression in animal models of …