Immune tolerance hinders the potentially destructive responses of lymphocytes to host
tissues. Tolerance is regulated at the stage of immature B cell development (central …

Each antibody-producing B cell makes antibodies of unique specificity, reflecting a series of
ordered gene rearrangements which must be successfully performed if the cell is to survive …

Failure of immunization with the HIV-1 envelope to induce broadly neutralizing antibodies
against conserved epitopes is a major barrier to producing a preventive HIV-1 vaccine …

The vast repertoire of immunoglobulins and T cell receptors is generated, in part, by V (D) J
recombination, a series of genomic rearrangements that occur specifically in developing …

We have resolved B220+ IgM-B-lineage cells in mouse bone marrow into four fractions
based on differential cell surface expression of determinants recognized by S7 (leukosialin …

Abstract V (D) J recombination is of fundamental importance to the generation of diverse
antigen receptor repertoires. We review our current understanding of the V (D) J …

The separate development of functionally intertwined lineages of lymphocytes known as B
cells and T cells is now recognized as a fundamental organizing principle of the adaptive …

The isolation of clones encoding the human surface protein T4, and the expression of the T4
gene in new cellular environments, have enabled us to examine the role of this protein in the …

The RAG-1 (recombination activating gene-l) genomic locus, which activates V (O) J
recombination when introduced into NIH 3T3 fibroblasts, was isolated by serial genomic …

The RAG endonuclease initiates Igh V (D) J assembly in B cell progenitors by joining D
segments to JH segments, before joining upstream VH segments to DJH intermediates. In …