Neuroinflammatory markers: key indicators in the pathology of neurodegenerative diseases
Neuroinflammation, a protective response of the central nervous system (CNS), is
associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of …
associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of …
Exploring the etiological links behind neurodegenerative diseases: Inflammatory cytokines and bioactive kynurenines
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common
neurodegenerative diseases (NDs), presenting a broad range of symptoms from motor …
neurodegenerative diseases (NDs), presenting a broad range of symptoms from motor …
IDO and kynurenine metabolites in peripheral and CNS disorders
YS Huang, J Ogbechi, FI Clanchy, RO Williams… - Frontiers in …, 2020 - frontiersin.org
The importance of the kynurenine pathway in normal immune system function has led to an
appreciation of its possible contribution to autoimmune disorders such as rheumatoid …
appreciation of its possible contribution to autoimmune disorders such as rheumatoid …
The involvement of intestinal tryptophan metabolism in inflammatory bowel disease identified by a meta-analysis of the transcriptome and a systematic review of the …
Evidence is emerging for the role of intestinal tryptophan metabolism in the development of
inflammatory bowel disease (IBD). In order to identify the role of altered intestinal tryptophan …
inflammatory bowel disease (IBD). In order to identify the role of altered intestinal tryptophan …
[HTML][HTML] Kynurenine pathway of tryptophan metabolism in neuropsychiatric disorders: pathophysiologic and therapeutic considerations
A Muneer - Clinical Psychopharmacology and Neuroscience, 2020 - ncbi.nlm.nih.gov
Under physiological conditions 95% of the ingested essential amino acid tryptophan is
metabolized by the kynurenine pathway (KP) to yield the ubiquitous co-enzyme …
metabolized by the kynurenine pathway (KP) to yield the ubiquitous co-enzyme …
[HTML][HTML] The kynurenine connection: How exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain
Tryptophan catabolism through the kynurenine pathway generates a variety of bioactive
metabolites. Physical exercise can modulate kynurenine pathway metabolism in skeletal …
metabolites. Physical exercise can modulate kynurenine pathway metabolism in skeletal …
Are kynurenines accomplices or principal villains in dementia? Maintenance of kynurenine metabolism
Worldwide, 50 million people suffer from dementia, a group of symptoms affecting cognitive
and social functions, progressing severely enough to interfere with daily life. Alzheimer's …
and social functions, progressing severely enough to interfere with daily life. Alzheimer's …
Kynurenine metabolism and alzheimer's disease: the potential targets and approaches
Abstract l-tryptophan, an essential amino acid, regulates protein homeostasis and plays a
role in neurotransmitter-mediated physiological events. It also influences age-associated …
role in neurotransmitter-mediated physiological events. It also influences age-associated …
[HTML][HTML] Intestinal tryptophan metabolism in disease prevention and swine production
Z Hu, L Feng, Q Jiang, W Wang, X Tang, Y Yin - Animal Nutrition, 2023 - Elsevier
Tryptophan (Trp) is an essential amino acid that cannot be synthesized by animals. It has
been characterized into two different isomers, levorotation-Trp (L-Trp) and dextrorotation-Trp …
been characterized into two different isomers, levorotation-Trp (L-Trp) and dextrorotation-Trp …
Metabolomics approach revealed robust changes in amino acid and biogenic amine signatures in patients with schizophrenia in the early course of the disease
M Parksepp, L Leppik, K Koch, K Uppin, R Kangro… - Scientific Reports, 2020 - nature.com
The primary objective of this study was to evaluate how schizophrenia (SCH) spectrum
disorders and applied antipsychotic (AP) treatment affect serum level of amino acids (AAs) …
disorders and applied antipsychotic (AP) treatment affect serum level of amino acids (AAs) …