The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Abstract hERG potassium channels are essential for normal electrical activity in the heart.
Inherited mutations in the HERG gene cause long QT syndrome, a disorder that predisposes …

Cardiac K+ channels are membrane-spanning proteins that allow the passive movement of
K+ ions across the cell membrane along its electrochemical gradient. They regulate the …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

The cardiac electrical system is designed to ensure the appropriate rate and timing of
contraction in all regions of the heart, which are essential for effective cardiac function. Well …

For the past decade, cardiac safety screening to evaluate the propensity of drugs to produce
QT interval prolongation and Torsades de Pointes (TdP) arrhythmia has been conducted …

For over 150 years Australia has exported bulk, undifferentiated, commodities such as wool,
wheat, meat and sugar to the UK and more recently to Japan, Korea, and the Middle East. It …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Numerosity, the number of elements in a set, is a most abstract quantitative category. As
such, it is independent of the sensory modality of its elements, ie, supramodal. Because …

Torsades de pointes is a potentially lethal arrhythmia that occasionally appears as an
adverse effect of pharmacotherapy. Recently developed understanding of the underlying …