From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery

KCF Bordon, CT Cologna, EC Fornari-Baldo… - Frontiers in …, 2020 - frontiersin.org
Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

[HTML][HTML] Peptide and peptide-based inhibitors of SARS-CoV-2 entry

D Schütz, YB Ruiz-Blanco, J Münch, F Kirchhoff… - Advanced drug delivery …, 2020 - Elsevier
To date, no effective vaccines or therapies are available against the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), the causative pandemic agent of the coronavirus …

Nanoparticles: oral delivery for protein and peptide drugs

S Cao, S Xu, H Wang, Y Ling, J Dong, R Xia, X Sun - Aaps Pharmscitech, 2019 - Springer
Protein and peptide drugs have many advantages, such as high bioactivity and specificity,
strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of …

Designing improved active peptides for therapeutic approaches against infectious diseases

B Gomes, MT Augusto, MR Felício, A Hollmann… - Biotechnology …, 2018 - Elsevier
Infectious diseases are one of the main causes of human morbidity and mortality. In the last
few decades, pathogenic microorganisms' resistance to conventional drugs has been …

Marine polysaccharides as a versatile biomass for the construction of nano drug delivery systems

Y Sun, X Ma, H Hu - Marine Drugs, 2021 - mdpi.com
Marine biomass is a treasure trove of materials. Marine polysaccharides have the
characteristics of biocompatibility, biodegradability, non-toxicity, low cost, and abundance …

Microneedles for gene and drug delivery in skin cancer therapy

D Zhi, T Yang, T Zhang, M Yang, S Zhang… - Journal of Controlled …, 2021 - Elsevier
The success of skin cancer treatment is severely limited in the route of administration
because most genes and drugs cannot break through the excellent stratum corneum (SC) …

Molecular engineering solutions for therapeutic peptide delivery

H Acar, JM Ting, S Srivastava, JL LaBelle… - Chemical Society …, 2017 - pubs.rsc.org
Proteins and their interactions in and out of cells must be well-orchestrated for the healthy
functioning and regulation of the body. Even the slightest disharmony can cause diseases …

[HTML][HTML] Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis

NL Denning, M Aziz, A Murao, SD Gurien, M Ochani… - JCI insight, 2020 - ncbi.nlm.nih.gov
Extracellular cold-inducible RNA-binding protein (eCIRP) is a recently discovered damage-
associated molecular pattern. Understanding the precise mechanism by which it …

Millet derived bioactive peptides: A review on their functional properties and health benefits

A Majid, P Priyadarshini CG - Critical reviews in food science and …, 2020 - Taylor & Francis
Millets, cereals and grains play an important role in providing adequate nutrition and as well
shown to possess beneficial effects on lifestyle disorders. Several studies on millet seed …

Natural and synthetic peptides with antifungal activity

T Ciociola, L Giovati, S Conti, W Magliani… - Future medicinal …, 2016 - Taylor & Francis
In recent years, the increase of invasive fungal infections and the emergence of antifungal
resistance stressed the need for new antifungal drugs. Peptides have shown to be good …