Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …

Advances in imaging technologies have revealed that many bacteria possess organelles
with a proteomically defined lumen and a macromolecular boundary. Some are bound by a …

Devices that interact with living organisms are typically made of metals, silicon, ceramics,
and plastics. Implantation of such devices for long-term monitoring or treatment generally …

It is unclear how the mitochondrial fusion protein Optic atrophy 1 (OPA1), which inhibits
cristae remodeling, protects from mitochondrial dysfunction. Here we identify the …

The mitochondrial contact site and cristae organizing system (MICOS) and Optic atrophy 1
(OPA1) control cristae shape, thus affecting mitochondrial function and apoptosis. Whether …

Mitochondria contain two membranes: the outer and inner membrane. Whereas the outer
membrane is particularly enriched in phospholipids, the inner membrane has an unusual …

Eukaryogenesis–the emergence of eukaryotic cells–represents a pivotal evolutionary event.
With a fundamentally more complex cellular plan compared to prokaryotes, eukaryotes are …

PINK1 and Parkin mediate mitophagy, the cellular process that clears dysfunctional
mitochondria. Mitophagy is regulated by mitochondrial dynamics, but the molecules linking …

Cristae are infoldings of the mitochondrial inner membrane jutting into the organelle's
innermost compartment from narrow stems at their base called crista junctions. They are …

Mitochondria are the respiratory organelles of eukaryotes and their evolutionary history is
deeply intertwined with that of eukaryotes. The compartmentalization of respiration in …