Drift and termination of spiral waves in optogenetically modified cardiac tissue at sub-threshold illumination
S Hussaini, V Venkatesan, V Biasci… - Elife, 2021 - elifesciences.org
The development of new approaches to control cardiac arrhythmias requires a deep
understanding of spiral wave dynamics. Optogenetics offers new possibilities for this …
understanding of spiral wave dynamics. Optogenetics offers new possibilities for this …
Mathematical modelling of active contraction in isolated cardiomyocytes
We investigate the interaction of intracellular calcium spatio-temporal variations with the self-
sustained contractions in cardiac myocytes. A consistent mathematical model is presented …
sustained contractions in cardiac myocytes. A consistent mathematical model is presented …
Terminating spiral waves with a single designed stimulus: Teleportation as the mechanism for defibrillation
N DeTal, A Kaboudian… - Proceedings of the …, 2022 - National Acad Sciences
We identify and demonstrate a universal mechanism for terminating spiral waves in
excitable media using an established topological framework. This mechanism dictates …
excitable media using an established topological framework. This mechanism dictates …
Dissolution of spiral wave's core using cardiac optogenetics
S Hussaini, SL Lädke… - PLOS Computational …, 2023 - journals.plos.org
Rotating spiral waves in the heart are associated with life-threatening cardiac arrhythmias
such as ventricular tachycardia and fibrillation. These arrhythmias are treated by a process …
such as ventricular tachycardia and fibrillation. These arrhythmias are treated by a process …
Adaptive electric shocks control and elimination of spiral waves using dynamic learning based techniques
Q Ding, Y Wu, W Huang, Y Hu, Y Xie, Y Jia - Nonlinear Dynamics, 2024 - Springer
The elimination of cardiac spiral waves by high-voltage defibrillation has significant side
effects, and low-intensity alternatives have long been in demand. The advances in AI …
effects, and low-intensity alternatives have long been in demand. The advances in AI …
Role of temperature on nonlinear cardiac dynamics
Thermal effects affecting spatiotemporal behavior of cardiac tissue are discussed by relating
temperature variations to proarrhythmic dynamics in the heart. By introducing a …
temperature variations to proarrhythmic dynamics in the heart. By introducing a …
In silico optical modulation of spiral wave trajectories in cardiac tissue
Life-threatening cardiac arrhythmias such as ventricular tachycardia and fibrillation are
common precursors to sudden cardiac death. They are associated with the occurrence of …
common precursors to sudden cardiac death. They are associated with the occurrence of …
Theoretical and numerical modeling of nonlinear electromechanics with applications to biological active media
We present a general theoretical framework for the formulation of the nonlinear
electromechanics of polymeric and biological active media. The approach developed here is …
electromechanics of polymeric and biological active media. The approach developed here is …
[图书][B] Patterns in excitable media: Genesis, dynamics, and control
Excitable media comprise a class of models for a wide range of physical, chemical, and
biological systems that exhibit spontaneous formation of spatial patterns. Patterns in …
biological systems that exhibit spontaneous formation of spatial patterns. Patterns in …
Phase-resolved analysis of the susceptibility of pinned spiral waves to far-field pacing in a two-dimensional model of excitable media
P Bittihn, A Squires, G Luther… - … of the Royal …, 2010 - royalsocietypublishing.org
Life-threatening cardiac arrhythmias are associated with the existence of stable and
unstable spiral waves. Termination of such complex spatio-temporal patterns by local control …
unstable spiral waves. Termination of such complex spatio-temporal patterns by local control …