Nuclear magnetic resonance spectroscopy in clinical metabolomics and personalized medicine: current challenges and perspectives

MPM Letertre, P Giraudeau, P De Tullio - Frontiers in Molecular …, 2021 - frontiersin.org
Personalized medicine is probably the most promising area being developed in modern
medicine. This approach attempts to optimize the therapies and the patient care based on …

Recent advances in targeted and untargeted metabolomics by NMR and MS/NMR methods

K Bingol - High-throughput, 2018 - mdpi.com
Metabolomics has made significant progress in multiple fronts in the last 18 months. This
minireview aimed to give an overview of these advancements in the light of their contribution …

NMR: unique strengths that enhance modern metabolomics research

AS Edison, M Colonna, GJ Gouveia… - Analytical …, 2020 - ACS Publications
Nuclear magnetic resonance (NMR) spectroscopy is an important analytical technique in
metabolomics. Because it provides atomic-level detail of small molecules, NMR is …

Current and future perspectives of functional metabolomics in disease studies–A review

M Yan, G Xu - Analytica chimica acta, 2018 - Elsevier
Functional metabolomics is a new concept, which studies the functions of metabolites and
related enzymes focused on metabolomics. It overcomes the shortcomings of traditional …

Quantification of lipids: model, reality, and compromise

S Khoury, C Canlet, MZ Lacroix, O Berdeaux, J Jouhet… - Biomolecules, 2018 - mdpi.com
Lipids are key molecules in various biological processes, thus their quantification is a crucial
point in a lot of studies and should be taken into account in lipidomics development. This …

Tools and resources for metabolomics research community: A 2017–2018 update

BB Misra, S Mohapatra - Electrophoresis, 2019 - Wiley Online Library
The scale at which MS‐and NMR‐based platforms generate metabolomics datasets for both
research, core, and clinical facilities to address challenges in the various sciences—ranging …

Remodeling of skeletal muscle myosin metabolic states in hibernating mammals

CTA Lewis, EG Melhedegaard, MM Ognjanovic… - Elife, 2024 - elifesciences.org
Hibernation is a period of metabolic suppression utilized by many small and large mammal
species to survive during winter periods. As the underlying cellular and molecular …

A Fluorinated Chaperone Gives X‐ray Crystal Structures of Acyclic Natural Product Derivatives up to 338 Molecular Weight

T Berking, J Hartenfels, C Lenczyk… - Angewandte …, 2024 - Wiley Online Library
Crystallizing molecules with long flexible chains is a challenge, making it difficult to perform
X‐ray crystallography. Chaperones can assist in the crystallization of compounds that do not …

1H-NMR metabolomics reveals a multitarget action of Crithmum maritimum ethyl acetate extract in inhibiting hepatocellular carcinoma cell growth

D Gnocchi, L Del Coco, CR Girelli, F Castellaneta… - Scientific Reports, 2021 - nature.com
Hepatocellular carcinoma (HCC) is nowadays the sixth cause of tumour-related deceases
worldwide, estimated to become the third in Western countries by 2030. New drugs for HCC …

[HTML][HTML] Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via …

V Ferreira, C Folgueira, M García-Altares, M Guillén… - Redox Biology, 2023 - Elsevier
Olanzapine (OLA), a widely used second-generation antipsychotic (SGA), causes weight
gain and metabolic alterations when administered orally to patients. Recently, we …