The Wnt/β-catenin signaling pathway is one of several key conserved intercellular signaling
pathways in animals, and plays fundamental roles in the proliferation, regeneration …

Diverse signaling cues and attendant proteins work together during organogenesis,
including craniofacial development. Lip and palate formation starts as early as the fourth …

During limb development, digits emerge from the undifferentiated mesenchymal tissue that
constitutes the limb bud. It has been proposed that this process is controlled by a self …

Background Understanding the dynamic cellular behaviors and underlying molecular
mechanisms that drive morphogenesis is an ongoing challenge in biology. Live imaging …

Post-natal skeletal stem cells expressing PRX1 (pnPRX1+) have been identified in the
calvaria and in the axial skeleton. Here we characterize the location and functional capacity …

In newborn humans, and up to approximately 2 y of age, calvarial bone defects can naturally
regenerate. This remarkable regeneration potential is also found in newborn mice and is …

The vertebrate head is an extremely complicated structure: development of the head
requires tissue–tissue interactions between derivates of all the germ layers and coordinated …

Craniofacial development, one of the most complex sequences of developmental events in
embryology, features a uniquely transient, pluripotent stem cell-like population known as the …

The etiology of non‐syndromic oral clefts (NSOFC) is complex with genetics, genomics,
epigenetics, and stochastics factors playing a role. Several approaches have been applied …

Abstract Objective To investigate SNPs in bone‐and cartilage‐related genes and their
interaction in the aetiology of sagittal and vertical skeletal malocclusions. Settings and …