AUF1 regulation of coding and noncoding RNA

EJF White, AE Matsangos… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
AUF1 is a family of four RNA‐binding proteins (RBP s) generated by alternative pre‐
messenger RNA (pre-mRNA) splicing, with canonical roles in controlling the stability and/or …

Two ways of escaping from oxidative RNA damage: Selective degradation and cell death

T Ishii, M Sekiguchi - DNA repair, 2019 - Elsevier
Reactive oxygen species (ROS) are produced during normal cellular metabolism, and
various oxidized compounds are formed by the ROS attack. Among oxidized bases, 8-oxo-7 …

Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence

N Noren Hooten, A Martin‐Montalvo, DF Dluzen… - Aging cell, 2016 - Wiley Online Library
Metformin, an oral hypoglycemic agent, has been used for decades to treat type 2 diabetes
mellitus. Recent studies indicate that mice treated with metformin live longer and have fewer …

AUF1 ligand circPCNX reduces cell proliferation by competing with p21 mRNA to increase p21 production

D Tsitsipatis, I Grammatikakis, RK Driscoll… - Nucleic acids …, 2021 - academic.oup.com
Mammalian circRNAs can influence different cellular processes by interacting with proteins
and other nucleic acids. Here, we used ribonucleoprotein immunoprecipitation (RIP) …

Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis

X Zhao, S Wei, Z Li, C Lin, Z Zhu, D Sun, R Bai… - Cell Death & …, 2019 - nature.com
Silica nanoparticles (SiNPs) have been reported to induce pulmonary fibrosis (PF) with an
unknown mechanism. Recently, the activation of autophagy, a lysosome-dependent cell …

The effect of two concurrent exercise modalities on serum concentrations of FGF21, irisin, follistatin, and myostatin in men with type 2 diabetes mellitus

M Motahari Rad, N Bijeh… - … of Physiology and …, 2023 - Taylor & Francis
This study investigated the effect of concurrent training (CT) sequences on fibroblast growth
factor 21 (FGF21), irisin, myostatin (MSTN), and follistatin (FST) among adults with type 2 …

Hypoxia-inducible microRNA-218 inhibits trophoblast invasion by targeting LASP1: Implications for preeclampsia development

M Fang, H Du, B Han, G Xia, X Shi, F Zhang… - The international journal …, 2017 - Elsevier
Preeclampsia (PE) is a major contributor to maternal morbidity and mortality. However, the
molecular mechanisms underlying PE progression are not well characterized. Here, we …

The emerging role of follistatin under stresses and its implications in diseases

L Zhang, K Liu, B Han, Z Xu, X Gao - Gene, 2018 - Elsevier
Abstract Follistatin (FST), a single-chain glycosylated protein, is expressed in various
tissues. The essential biological function of FST is binding and neutralizing transforming …

Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis

X Liang, R Xie, J Su, B Ye, S Wei, Z Liang, R Bai… - Journal of Experimental …, 2019 - Springer
Background Upregulation of RNA polymerase (Pol) III products, including tRNAs and 5S
rRNA, in tumor cells leads to enhanced protein synthesis and tumor formation, making it a …

Pharmacological and physiological activation of AMPK improves the spliceopathy in DM1 mouse muscles

A Ravel-Chapuis, A Al-Rewashdy… - Human molecular …, 2018 - academic.oup.com
Abstract Myotonic dystrophy type 1 (DM1) is a debilitating multisystemic disorder caused by
a triplet repeat expansion in the 3'untranslated region of dystrophia myotonica protein …