Macrophages are often viewed through the lens of their core functions, but recent
transcriptomic studies reveal them to be largely distinct across tissue types. While these …

Objectives and design Chlorogenic acid, which belongs to the polyphenols, is an anti-
oxidant and anti-obesity agent. In this study, we investigated the role of chlorogenic acid in …

The WNT signalling cascades have emerged as critical regulators of a wide variety of
biological aspects involved in lung development as well as in physiological and …

Objectives and design Arbutin, which is found in the genus Arctostaphylos, is an anti-oxidant
and a depigmenting agent. The present study was designed to validate the anti …

There are different polarization states of macrophages, including the classically activated M1
phenotype and the alternatively activated M2 phenotype. These have different functions in …

The β-catenin dependent canonical Wnt signaling pathway plays a crucial role in
maintaining normal homeostasis. However, when dysregulated, Wnt signaling is closely …

Neutrophil infiltration represents the early acute inflammatory response in acute lung injury.
The recruitment of neutrophils from the peripheral blood across the endothelial-epithelial …

Abstract β-elemene, extracted from Rhizoma zedoariae, has been widely used as a
traditional medicine for its antitumor activity against a broad range of cancers. However, the …

The Wnt/β-catenin pathway has been involved in regulating inflammation in various
infectious and inflammatory diseases. Sepsis is a life-threatening condition caused by …

Transcription factor-7-like-2 (TCF7L2), a vital member of the T-cell factor/lymphoid enhancer
factor (TCF/LEF) family, plays an important role in normal human physiological and …