[HTML][HTML] Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway

Y Huang, X Zhu, K Chen, H Lang, Y Zhang… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Background: The concept of sarcopenic obesity refers to low muscle mass coupled with high
adiposity in older adults. Sarcopenic obesity is a new medical challenge that imposes …

Exercise cuts both ways with ROS in remodifying innate and adaptive responses: Rewiring the redox mechanism of the immune system during exercise

A Thirupathi, Y Gu, RA Pinho - Antioxidants, 2021 - mdpi.com
Nearly all cellular functions depend on redox reactions, including those of immune cells.
However, how redox reactions are rearranged to induce an immune response to the entry of …

Gardeniae fructus attenuates thioacetamide-induced liver fibrosis in mice via both AMPK/SIRT1/NF-κB pathway and Nrf2 signaling

MR Shin, JA Lee, M Kim, S Lee, M Oh, J Moon… - Antioxidants, 2021 - mdpi.com
Liver fibrosis, which means a sort of the excessive accumulation of extracellular matrices
(ECMs) components through the liver tissue, is considered as tissue repair or wound …

Effect of quercetin on lipids metabolism through modulating the gut microbial and AMPK/PPAR signaling pathway in broilers

M Wang, B Wang, S Wang, H Lu, H Wu… - Frontiers in Cell and …, 2021 - frontiersin.org
The present study was conducted to investigate effects and mechanism of quercetin on
lipids metabolism in broilers. 480 AA broilers were randomly allotted to four treatments (0 …

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11–JAK/STAT3 pathway

S Ollila, E Domènech-Moreno… - The Journal of …, 2018 - Am Soc Clin Investig
Germline mutations in the gene encoding tumor suppressor kinase LKB1 lead to
gastrointestinal tumorigenesis in Peutz-Jeghers syndrome (PJS) patients and mouse …

Loss of LKB1-NUAK1 signalling enhances NF-κB activity in a spheroid model of high-grade serous ovarian cancer

A Buensuceso, JL Fritz, O Collins, YR Valdés… - Scientific Reports, 2022 - nature.com
High-grade serous ovarian cancer (HGSOC) is an aggressive malignancy often diagnosed
at an advanced stage. Although most HGSOC patients respond initially to debulking surgery …

LKB1/p53/TIGAR/autophagy-dependent VEGF expression contributes to PM2. 5-induced pulmonary inflammatory responses

H Xu, X Xu, H Wang, A Qimuge, S Liu, Y Chen… - Scientific Reports, 2019 - nature.com
One of the health hazards of PM2. 5 exposure is to induce pulmonary inflammatory
responses. In our previous study, we demonstrated that exposing both the immortalized and …

The effect of caffeine on skeletal muscle anabolic signaling and hypertrophy

TM Moore, XM Mortensen, CK Ashby… - Applied Physiology …, 2017 - cdnsciencepub.com
Caffeine is a widely consumed stimulant with the potential to enhance physical performance
through multiple mechanisms. However, recent in vitro findings have suggested that caffeine …

[HTML][HTML] Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced …

T Chen, JT Hill, TM Moore, ECK Cheung… - … Et Biophysica Acta (BBA …, 2020 - Elsevier
Ad libitum high-fat diet (HFD) induces obesity and skeletal muscle metabolic dysfunction.
Liver kinase B1 (LKB1) regulates skeletal muscle metabolism by controlling the AMP …

Liver kinase B1 overexpression controls mycobacterial infection in macrophages via FOXO1/Wnt5a signaling

J Cui, M Li, W Liu, B Zhang, B Sun… - Journal of cellular …, 2019 - Wiley Online Library
Mycobacterium tuberculosis (Mtb) is a primary cause of tuberculosis (TB), which has infected
more than one‐third of the world's population. Mtb survival and subsequent inflammation in …