MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs that regulate gene
expression. Alteration in miRNA expression results in changes in the profile of genes …

Nucleic acid‐based therapeutics that regulate gene expression have been developed
towards clinical use at a steady pace for several decades, but in recent years the field has …

Circular RNAs (circRNAs) are stable and prevalent RNAs in eukaryotic cells that arise from
back-splicing. Synthetic circRNAs and some endogenous circRNAs can encode proteins …

MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that
are produced in a tissue and time-specific manner to orchestrate gene expression post …

Aptamers are single-stranded DNA or RNA molecules capable of tightly binding to specific
targets. These functional nucleic acids are obtained by an in vitro Darwinian evolution …

MicroRNAs (miRNAs) are non-coding endogenous RNAs that direct post-transcriptional
regulation of gene expression by several mechanisms. Activity is primarily through binding …

There are few disease-modifying therapeutics for neurodegenerative diseases, but
successes on the development of antisense oligonucleotide (ASO) therapeutics for spinal …

Oligonucleotides (ONs), and their chemically modified mimics, are now routinely used in the
laboratory as a means to control the expression of fundamentally interesting or …

The majority of currently available drugs and tool compounds exhibit an inhibitory
mechanism of action and there is a relative lack of pharmaceutical agents that are capable …

Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …