The Impact of lncRNAs in Diabetes Mellitus: A Systematic Review and In Silico Analyses

C Dieter, NE Lemos, NRF Corrêa… - Frontiers in …, 2021 - frontiersin.org
Long non-coding RNAs (lncRNAs) are non-coding transcripts that have emerged as one of
the largest and diverse RNA families that regulate gene expression. Accumulating evidence …

Current insights into miRNA and lncRNA dysregulation in diabetes: signal transduction, clinical trials and biomarker discovery

A Pandey, S Ajgaonkar, N Jadhav, P Saha, P Gurav… - Pharmaceuticals, 2022 - mdpi.com
Diabetes is one of the most frequently occurring metabolic disorders, affecting almost one
tenth of the global population. Despite advances in antihyperglycemic therapeutics, the …

Bioinformatics Analysis of Next Generation Sequencing Data Identifies Molecular Biomarkers Associated With Type 2 Diabetes Mellitus

V Alur, V Raju, B Vastrad, C Vastrad… - Clinical Medicine …, 2023 - journals.sagepub.com
Background: Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder. The
aim of the present investigation was to identify gene signature specific to T2DM. Methods …

LncRNA CTBP1-AS2 alleviates high glucose-induced oxidative stress, ECM accumulation, and inflammation in diabetic nephropathy via miR-155-5p/FOXO1 axis

G Wang, B Wu, B Zhang, K Wang, H Wang - Biochemical and biophysical …, 2020 - Elsevier
Background This study aimed to investigate the involvement of lncRNA CTBP1-AS2 in the
progression of diabetic nephropathy (DN) by affecting high glucose (HG)-induced human …

Er: YAG laser alleviates inflammaging in diabetes-associated periodontitis via activation CTBP1-AS2/miR-155/SIRT1 Axis

MY Ng, CC Yu, SH Chen, YW Liao, T Lin - International Journal of …, 2024 - mdpi.com
Periodontitis is a significant health concern for individuals with diabetes mellitus (DM),
characterized by inflammation and periodontium loss. Hyperglycaemia in DM exacerbates …

Downregulating long Non-coding RNAs CTBP1-AS2 inhibits colorectal cancer development by modulating the miR-93-5p/TGF-β/SMAD2/3 pathway

Q Li, W Yue, M Li, Z Jiang, Z Hou, W Liu, N Ma… - Frontiers in …, 2021 - frontiersin.org
Background: Colorectal cancer (CRC), the most commonly diagnosed cancer in the world,
has a high mortality rate. In recent decades, long non-coding RNAs (lncRNAs) have been …

Non-coding RNAs and type 2 diabetes mellitus

M Taheri, R Eghtedarian, S Ghafouri-Fard… - … of Physiology and …, 2023 - Taylor & Francis
Type 2 diabetes mellitus (T2DM) is a worldwide disease with rapidly increasing prevalence.
This complex disorder caused by interplay between genetic predisposition factors, early …

Non-coding RNAs based molecular links in type 2 diabetes, ischemic stroke, and vascular dementia

M Vijayan, PH Reddy - Journal of Alzheimer's Disease, 2020 - content.iospress.com
This article reviews recent advances in the study of microRNAs (miRNAs), long non-coding
RNAs (lncRNAs), and their functions in type 2 diabetes mellitus (T2DM), ischemic stroke (IS) …

LncRNA CTBP1-AS2 is upregulated in osteoarthritis and increases the methylation of miR-130a gene to inhibit chondrocyte proliferation

H Zhang, J Li, W Shao, N Shen - Clinical Rheumatology, 2020 - Springer
Abstract Objectives LncRNA CTBP1-AS2 has been reported to be involved in type 2
diabetes and cardiomyocyte hypertrophy, while its roles in other human diseases are …

Long non-coding RNAs (lncRNAs) in cardiovascular disease complication of type 2 diabetes

N Ismail, N Abdullah, NA Abdul Murad, R Jamal… - Diagnostics, 2021 - mdpi.com
The discovery of non-coding RNAs (ncRNAs) has opened a new paradigm to use ncRNAs
as biomarkers to detect disease progression. Long non-coding RNAs (lncRNA) have …