Quinolones are one of the most commonly prescribed classes of antibacterials in the world
and are used to treat a variety of bacterial infections in humans. Because of the wide use …

Quinolones are broad-spectrum synthetic antibacterial drugs first obtained during the
synthesis of chloroquine. Nalidixic acid, the prototype of quinolones, first became available …

After two decades of the discovery of plasmid-mediated quinolone resistance (PMQR), three
different mechanisms have been associated to this phenomenon: target protection (Qnr …

Quinolones are a family of synthetic broad-spectrum antimicrobial drugs. These molecules
have been widely prescribed to treat various infectious diseases and have been classified …

Escherichia coli ST131 is a recently emerged antibiotic resistant clone responsible for high
rates of urinary tract and bloodstream infections. Despite its global dominance, the precise …

Emerging antimicrobial resistance is a major threat to human's health in the 21st century.
Understanding and combating this issue requires a full and unbiased assessment of the …

Current antibiotic testing does not include the potential influence of host cell environment on
microbial susceptibility and antibiotic resistance, hindering appropriate therapeutic …

Beyond their requisite functions in many critical DNA processes, the bacterial type II
topoisomerases, gyrase and topoisomerase IV, are the targets of fluoroquinolone …

Ceragenins constitute a novel family of cationic antibiotics characterized by a broad
spectrum of antimicrobial activities, which have mostly been assessed in vitro. Using a …

Objectives aac (6′)-Ib-cr is the most prevalent plasmid-mediated fluoroquinolone (FQ)
resistance mechanism in Enterobacteriaceae. We aimed to analyse the interplay between …