Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …

Cysteine sulfinic acid or S-sulfinylation is an oxidative post-translational modification
(OxiPTM) that is known to be involved in redox-dependent regulation of protein function but …

The NRF2/KEAP1 pathway is a fundamental signaling cascade that controls multiple
cytoprotective responses through the induction of a complex transcriptional program that …

Abstract Sulfiredoxin 1 (SRXN1) is a pivotal regulator of the antioxidant response in
eukaryotic cells. However, the role of SRXN1 in hepatocellular carcinoma (HCC) is far from …

Significance: It has been proposed that cancer cells are heavily dependent on their
antioxidant defenses for survival and growth. Peroxiredoxins are a family of abundant thiol …

Occurrence of oxidative stress is the principal cause of acute kidney injury induced by
cisplatin. Mangiferin, a naturally occurring antioxidant molecule, is found to ameliorate …

Ferroptosis, a recently identified non-apoptotic form of cell death, is strongly associated with
neurological diseases and has emerged as a potential therapeutic target. Nevertheless, the …

In this study, erianin was found to reduce the viability of cancer cells, inhibit their proliferation
and migration, induce G2/M phase arrest, enhance cancer cell apoptosis, promote an …

Cardiac stem/progenitor cells (CPCs) have recently emerged as a potentially transformative
regenerative medicine to repair the infarcted heart. However, the limited survival of donor …