Background and Objectives: Myelomeningocele is the most severe form of spina bifida, a
congenital neural tube defect arising from an incomplete neural tube closure during early …

Objective We performed a systematic review to summarize the efficacy and safety of in utero
stem cells application in preclinical models with myelomeningocele (MMC). Methods The …

BACKGROUND AND PURPOSE: Short-term results demonstrate that prenatal repair of a
myelomeningocele is associated with a reduction in hydrocephalus and an increased …

Introduction Open fetal myelomeningocele (MMC) surgery is currently the standard of care
option for prenatal MMC repair. We described the population referred to our center and …

Surgery during pregnancy is a topic of much debate with clinical practice often governed by
gestalt and past practice. In the last 20 years or so, investigators have sought to establish …

The management of myelomeningocele study trial showed significant prognostic
improvement in fetal repair before 26 weeks of gestation. Hence, surgery in utero represents …

OBJECTIVE This study aimed to investigate prenatal predictors of the need for cerebrospinal
fluid diversion in infants following prenatal repair of open spina bifida. DATA SOURCES A …

Myelomeningocele (MMC) is a congenital defect of the spine characterised by meningeal
and spinal cord protrusion through the open vertebral arches. This defect causes …

OBJECTIVE Despite in utero spina bifida (SB) repair, more than two-thirds of patients with
SB are unable to ambulate independently, and 1 in 4 children need surgery for tethered cord …

Myelomeningocele is a birth defect whose clinical manifestations are due both to incomplete
neural tube closure and the progressive destruction of exposed neuroepithelium during …