Phase separation in immune signalling
Immune signalling pathways convert pathogenic stimuli into cytosolic events that lead to the
resolution of infection. Upon ligand engagement, immune receptors together with their …
resolution of infection. Upon ligand engagement, immune receptors together with their …
Regulatory mechanisms in T cell receptor signalling
The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …
intracellular signals required for T cell development, repertoire selection and effector …
Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells
T cells react to foreign or self-antigens through T cell receptor (TCR) signaling. Several
decades of research have delineated the mechanism of TCR signal transduction and its …
decades of research have delineated the mechanism of TCR signal transduction and its …
Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
T cell–antigen receptor (TCR) signaling requires the sequential activities of the kinases Lck
and Zap70. Upon TCR stimulation, Lck phosphorylates the TCR, thus leading to the …
and Zap70. Upon TCR stimulation, Lck phosphorylates the TCR, thus leading to the …
Quantitative interactomics in primary T cells provides a rationale for concomitant PD-1 and BTLA coinhibitor blockade in cancer immunotherapy
J Celis-Gutierrez, P Blattmann, Y Zhai, N Jarmuzynski… - Cell reports, 2019 - cell.com
Deciphering how TCR signals are modulated by coinhibitory receptors is of fundamental
and clinical interest. Using quantitative interactomics, we define the composition and …
and clinical interest. Using quantitative interactomics, we define the composition and …
TCR signal strength and T cell development
NRJ Gascoigne, V Rybakin, O Acuto… - Annual review of cell …, 2016 - annualreviews.org
Thymocyte selection involves the positive and negative selection of the repertoire of T cell
receptors (TCRs) such that the organism does not suffer autoimmunity, yet has the benefit of …
receptors (TCRs) such that the organism does not suffer autoimmunity, yet has the benefit of …
THEMIS-SHP1 recruitment by 4-1BB tunes LCK-mediated priming of chimeric antigen receptor-redirected T cells
Chimeric antigen receptor (CAR) T cell costimulation mediated by CD28 and 4-1BB is
essential for CAR-T cell-induced tumor regression. However, CD28 and 4-1BB differentially …
essential for CAR-T cell-induced tumor regression. However, CD28 and 4-1BB differentially …
Phenotypic models of T cell activation
M Lever, PK Maini, PA Van Der Merwe… - Nature Reviews …, 2014 - nature.com
T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on
the binding parameters that govern the interactions between T cell receptors (TCRs) and …
the binding parameters that govern the interactions between T cell receptors (TCRs) and …
How the T cell signaling network processes information to discriminate between self and agonist ligands
T cells exhibit remarkable sensitivity and selectivity in detecting and responding to agonist
peptides (p) bound to MHC molecules in a sea of self pMHC molecules. Despite much work …
peptides (p) bound to MHC molecules in a sea of self pMHC molecules. Despite much work …
[HTML][HTML] A Jurkat 76 based triple parameter reporter system to evaluate TCR functions and adoptive T cell strategies
S Rosskopf, J Leitner, W Paster, LT Morton… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Adoptive T cell therapy using TCR transgenic autologous T cells has shown great potential
for the treatment of tumor patients. Thorough characterization of genetically reprogrammed T …
for the treatment of tumor patients. Thorough characterization of genetically reprogrammed T …