In cancer patients, dendritic cells (DCs) in tumor-draining lymph nodes can present antigens
to naive T cells in ways that break immunological tolerance. The clonally expanded progeny …

The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and
non-canonical signalling pathways, which differ in both signalling components and …

Anti-PD-1 immune checkpoint blockers can induce sustained clinical responses in cancer
but how they function in vivo remains incompletely understood. Here, we combined intravital …

CD40 is a TNF receptor superfamily member expressed on both immune and non-immune
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …

Indoleamine 2, 3-dioxygenase (IDO) is the first and rate limiting catabolic enzyme in the
degradation pathway of the essential amino acid tryptophan. By cleaving the aromatic indole …

In this review, we focus on the function of CD40–CD40L (CD154) interactions in the
regulation of dendritic cell (DC)–T cell and DC–B cell crosstalk. In addition, we examine …

Protective immune responses against respiratory pathogens, such as severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus, are initiated by the …

Transcriptional reactivation of TERT, the catalytic subunit of telomerase, is necessary for
cancer progression in about 90% of human cancers. The recent discovery of two prevalent …

Nuclear‐factor κB (NF‐κB) transcription factors are activated by a wide variety of stimuli in
diverse cell types and control key aspects of immune function and development. Receptor …

The NF-κB protein RelB controls dendritic cell (DC) maturation and may be targeted
therapeutically to manipulate T cell responses in disease. Here we report that RelB …