Animal models for COVID-19: advances, gaps and perspectives
C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …
Yellow fever virus: knowledge gaps impeding the fight against an old foe
Yellow fever (YF) was one of the most dangerous infectious diseases of the 18th and 19th
centuries, resulting in mass casualties in Africa and the Americas. The etiologic agent is …
centuries, resulting in mass casualties in Africa and the Americas. The etiologic agent is …
Building the next generation of humanized hemato-lymphoid system mice
T Martinov, KM McKenna, WH Tan, EJ Collins… - Frontiers in …, 2021 - frontiersin.org
Since the late 1980s, mice have been repopulated with human hematopoietic cells to study
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …
Advanced model systems and tools for basic and translational human immunology
There are fundamental differences between humans and the animals we typically use to
study the immune system. We have learned much from genetically manipulated and inbred …
study the immune system. We have learned much from genetically manipulated and inbred …
[HTML][HTML] Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection
DJ Kenney, AK O'Connell, J Turcinovic, P Montanaro… - Cell reports, 2022 - cell.com
The human immunological mechanisms defining the clinical outcome of SARS-CoV-2
infection remain elusive. This knowledge gap is mostly driven by the lack of appropriate …
infection remain elusive. This knowledge gap is mostly driven by the lack of appropriate …
Advancing the understanding of NAFLD to hepatocellular carcinoma development: From experimental models to humans
K Chen, J Ma, X Jia, W Ai, Z Ma, Q Pan - Biochimica et Biophysica Acta …, 2019 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has recently been recognized as an important
etiology contributing to the increased incidence of hepatocellular carcinoma (HCC). NAFLD …
etiology contributing to the increased incidence of hepatocellular carcinoma (HCC). NAFLD …
Generation and characterization of genetically and antigenically diverse infectious clones of dengue virus serotypes 1–4
Dengue is caused by four genetically distinct viral serotypes, dengue virus (DENV) 1-4.
Following transmission by Aedes mosquitoes, DENV can cause a broad spectrum of …
Following transmission by Aedes mosquitoes, DENV can cause a broad spectrum of …
Animal models used in hepatitis C virus research
KA Berggren, S Suzuki, A Ploss - International journal of molecular …, 2020 - mdpi.com
The narrow range of species permissive to infection by hepatitis C virus (HCV) presents a
unique challenge to the development of useful animal models for studying HCV, as well as …
unique challenge to the development of useful animal models for studying HCV, as well as …
Animal models of hepatitis C virus infection
A Ploss, A Kapoor - Cold Spring Harbor …, 2020 - perspectivesinmedicine.cshlp.org
Hepatitis C virus (HCV) is an important and underreported infectious disease, causing
chronic infection in∼ 71 million people worldwide. The limited host range of HCV, which …
chronic infection in∼ 71 million people worldwide. The limited host range of HCV, which …
A roadmap for translational cancer glycoimmunology at single cell resolution
Cancer cells can evade immune responses by exploiting inhibitory immune checkpoints.
Immune checkpoint inhibitor (ICI) therapies based on anti-CTLA-4 and anti-PD-1/PD-L1 …
Immune checkpoint inhibitor (ICI) therapies based on anti-CTLA-4 and anti-PD-1/PD-L1 …