The chromatin-based rule governing the selection and activation of replication origins in
metazoans remains to be investigated. Here we report that NFIB, a member of Nuclear …

Cellular senescence of normal human cells has by now far exceeded its initial role as a
model system for aging research. Many reports show the accumulation of senescent cells in …

The sepsis initial hyperinflammatory reaction, if not treated early, shifts to a protracted state
of immunosuppression that alters both innate and adaptive immunity and is associated with …

Diabetes increases the likelihood of fracture, interferes with fracture healing and impairs
angiogenesis. The latter may be significant due to the critical nature of angiogenesis in …

Background Survival for patients with castration-resistant prostate cancer is highly variable.
We assessed the effectiveness of a whole-blood RNA transcript-based model as a …

Our previous studies have demonstrated that nuclear factor IC (NFI-C) null mice developed
short molar roots that contain aberrant odontoblasts and abnormal dentin formation. Based …

The mmu-miR-290-295 cluster codes for a family of microRNAs (miRNAs) that are
expressed de novo during early embryogenesis and are specific for mouse embryonic stem …

Simple Summary In this study, we found that metformin could inhibit the cell proliferation of
Oral Squamous Cell Carcinoma (OSCC) by promoting apoptosis and blocking the cell cycle …

Nuclear factor IC (NFI-C) plays a pivotal role in various cellular processes such as
odontoblast and osteoblast differentiation. Nfic-deficient mice showed abnormal tooth and …

Triple‐negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited
treatment options and poor prognosis. There is an urgent need to identify and understand …